Abstract
Background: Many inflammatory phenotypes previously described in adults with asthma: eosinophilic and non-eosinophilic. Treatment strategies based on these phenotypes have been successful. This study tried to evaluate sputum cytology in school aged asthmatics and to classify sputum inflammatory phenotypes in this age group.
Methods: Complete history, physical examination and asthma control test were performed to all children and adolescents. Pulmonary function tests, CBCs, renal function, sputum induction, processing, homogenization, centrifugation and count were done.
Results: This study included65 children and adolescents with mean age (11.9) 39 mild to moderate asthma (group1) and 26 with severe asthma (group2) according to pre bronchodilator FEV1% (Forced expiratory volume one). Group 1 mean age of was 12.2 ± 2.9 and was 11.43 ± 3.1 for group 2 (p value >0.05). Our study shows eosinophilic phenotype had more uncontrolled (8 patients) and partially controlled patients (7 patients), while only 4 contolled patients had eosinophilic sputum. In neurtrophilic type, most patients were controlled (9 patients) while 3 patients were partially controlled and 3 patients were uncontrolled. Most patients were controlled (8 patients) in paucigranulocytic type while 3 patients were partially controlled and 2 patients were uncontrolled. The last type is mixed in which patients were controlled (10 patients) while 3 patients were partially controlled and 2 patients were uncontrolled. P value is significant as regard level of control
Keywords: asthma phenotypes; induced sputum; children.
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Corresponding Author
Elham Abdelhady Abdelghany
Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Minia University
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.169
