Title: HIV Infection and Malignancy
Author: Iddah, M. Ali
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.124
Abstract
HIV-infected individuals have an increased propensity to develop malignancy. The spectrum of neoplasia in these patients is changing, especially in developed portions of the world, where the widespread use of highly active antiretroviral therapy (HAART) has limited the immunosuppression associated with HIV for prolonged periods in most patients. Early in the AIDS epidemic, a dramatic increase in Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), and cervical cancer was noted, and these tumors ultimately were classified as AIDS-defining cancers. With the widespread use of potent antiretroviral therapy (ART), there was a dramatic decrease in the incidence of KS and NHL and a significant increase in the incidence of several other malignancies (non-AIDS-defining cancers). An understanding of the epidemiology and risk factors for these malignancies, in association with the prolonged survival of HIV-infected people in the ART era, increases the importance of adherence to cancer screening recommendations and prevention measures. Although the biology of malignancy in HIV infected people is often more aggressive than in those without HIV infection, standard treatment is generally indicated and can be associated with a favorable outcome, depending upon the tumor type, stage, and comorbidity. This paper will review general management considerations for patients with HIV and a malignancy, as well as a discussion of specific malignancies.
References
- Bower M, Collins S, Cottrill C, et al. British HIV Association guidelines for HIV-associated malignancies 2008. HIV Med 2008; 9:336.
- Deeken JF, Tjen-A-Looi A, Rudek MA, et al. The rising challenge of non-AIDS-defining cancers in HIV-infected patients. Clin Infect Dis 2012; 55:1228.
- Simard EP, Pfeiffer RM, Engels EA. Cumulative incidence of cancer among individuals with acquired immunodefi-ciency syndrome in the United States. Cancer 2011; 117:1089.
- Tyerman Z, Aboulafia DM. Review of screening guidelines for non-AIDS-defining malignancies: evolving issues in the era of highly active antiretroviral therapy. AIDS Rev 2012; 14:3.
- file://www.europeanaidsclinicalsociety.org/ (Accessed on August 30, 2012).
- Nelson L, Fried M, Stewart K. The risks of surgery in HIV-infected patients. J Perioper Pract 2007; 17:470, 472.
- Harris HW, Schecter WP. Surgical risk assessment and management in patients with HIV disease. Gastroenterol Clin North Am 1997; 26:377.
- Martin JN, Ganem DE, Osmond DH, et al. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998; 338:948.
- Maiman M, Fruchter RG, Serur E, et al. Human immunodeficiency virus infection and cervical neoplasia. Gynecol Oncol 1990; 38:377.
- Robinson W 3rd. Invasive and preinvasive cervical neoplasia in human immunodeficiency virus-infected women. Semin Oncol 2000; 27:463.
- Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodef-iciency syndrome. J Natl Cancer Inst 2000; 92:1500.
- Clifford GM, Rickenbach M, Lise M, et al. Hodgkin lymphoma in the Swiss HIV Cohort Study. Blood 2009; 113:5737.
- Hentrich M, Berger M, Wyen C, et al. Stage-adapted treatment of HIV-associated Hodgkin lymphoma: results of a prospective multicenter study. J ClinOncol 2012; 30:4117.
- Montoto S, Shaw K, Okosun J, et al. HIV Status Does Not Influence Outcome in Patients With Classical Hodgkin Lymphoma Treated With Chemotherapy Using Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine in the Highly Active Antiretroviral Therapy Era. J ClinOncol 2012.
- Frisch M, Biggar RJ, Engels EA, et al. Association of cancer with AIDS-related immunosuppression in adults. JAMA 2001; 285:1736.
- Powles T, Robinson D, Stebbing J, et al. Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection. J ClinOncol 2009; 27:884.
- Clifford GM, Polesel J, Rickenbach M, et al. Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst 2005; 97:425.
- Herida M, Mary-Krause M, Kaphan R, et al. Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients. J ClinOncol 2003; 21:3447.
- Lanoy E, Rosenberg PS, Fily F, et al. HIV-associated Hodgkin lymphoma during the first months on combination antiretroviral therapy. Blood 2011; 118:44.
- Levine AM. HIV-associated Hodgkin's disease. Biologic and clinical aspects. Hematol Oncol Clin North Am 1996; 10:1135.
- Costello R, Heuberger L, Petit N, et al. [Hodgkin's disease in patients infected with the human immunodeficiency virus]. Rev Med Interne 1998; 19:558.
- Hilman S, Brammer C. Human immunodeficiency virus-associated Hodgkin's disease of the anal canal. Clin Oncol (R CollRadiol) 2005; 17:69.
- Doweiko J, Dezube BJ, Pantanowitz L. Unusual sites of Hodgkin's lymphoma: CASE 1. HIV-associated Hodgkin's lymphoma of the stomach. J ClinOncol 2004; 22:4227.
- Cheung MC, Pantanowitz L, Dezube BJ. AIDS-related malignancies: emerging challenges in the era of highly active antiretroviral therapy. Oncologist 2005; 10:412.
- Kaplan LD. Management of HIV-associated Hodgkin lymphoma: how far we have come. J ClinOncol 2012; 30:4056.
- Xicoy B, Ribera JM, Miralles P, et al. Results of treatment with doxorubicin, bleomycin, vinblastine and dacarbazine and highly active antiretroviral therapy in advanced stage, human immunodeficiency virus-related Hodgkin's lymphoma. Haematologica 2007; 92:191.
- Spina M, Gabarre J, Rossi G, et al. Stanford V regimen and concomitant HAART in 59 patients with Hodgkin disease and HIV infection. Blood 2002; 100:1984.
- Dezube BJ, Aboulafia DM, Pantanowitz L. Plasma cell disorders in HIV-infected patients: from benign gammopathy to multiple myeloma. AIDS Read 2004; 14:372.
- Salarieh A, Rao C, Gottesman SR, et al. Plasma cell tumors in HIV-positive patients: report of a case and review of the literature. Leuk Lymphoma 2005; 46:1067.
- Amara S, Dezube BJ, Cooley TP, et al. HIV-associated monoclonal gammopathy: a retrospective analysis of 25 patients. Clin Infect Dis 2006; 43:1198.
- Fiorino AS, Atac B. Paraproteinemia, plasmacytoma, myeloma and HIV infection. Leukemia 1997; 11:2150.
- Konstantinopoulos PA, Dezube BJ, Pantanowitz L, et al. Protein electrophoresis and immunoglobulin analysis in HIV-infected patients. Am J ClinPathol 2007; 128:596.
- Larussa D, Grisetti S, Pilozzi E, et al. Acute megakaryoblastic leukemia in a patient receiving HAART. Am J Hematol 2005; 80:89.
- Manfredi R, Sabbatani S, Chiodo F. Advanced acute myelogenousleukaemia (AML) during HAART-treated HIV disease, manifesting initially as a thyroid mass. Scand J Infect Dis 2005; 37:781.
- Breccia M, Gentile G, Martino P, et al. Acute myeloid leukemia secondary to a myelodysplastic syndrome with t(3;3) (q21;q26) in an HIV patient treated with chemotherapy and highly active antiretroviral therapy. ActaHaematol 2004; 111:160.
- Kudva GC, Maliekel K, Richart JM, et al. Acute promyelocytic leukemia and HIV-1 infection: case report and review of the literature. Am J Hematol 2004; 77:287.
- Aboulafia DM, Meneses M, Ginsberg S, et al. Acute myeloid leukemia in patients infected with HIV-1. AIDS 2002; 16:865.
- Franceschi S, Lise M, Clifford GM, et al. Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study. Br J Cancer 2010; 103:416.
- Mani D, Dorer RK, Aboulafia DM. Therapy-related acute myeloid leukemia following HIV-associated lymphoma. Clin Lymphoma Myeloma 2009; 9:316.
- Sahasrabuddhe VV, Shiels MS, McGlynn KA, Engels EA. The risk of hepatocellular carcinoma among individuals with acquired immunodeficiency syndrome in the United States. Cancer 2012; 118:6226.
- Patel P, Hanson DL, Sullivan PS, et al. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003. Ann Intern Med 2008; 148:728.
- Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007; 370:59.
- Benard A, Bonnet F, Tessier JF, et al. Tobacco addiction and HIV infection: toward the implementation of cessation programs. ANRS CO3 Aquitaine Cohort. AIDS Patient Care STDS 2007; 21:458.
- Clifford GM, Lise M, Franceschi S, et al. Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection. Br J Cancer 2012; 106:447.
- Kirk GD, Merlo C, O' Driscoll P, et al. HIV infection is associated with an increased risk for lung cancer, independent of smoking. Clin Infect Dis 2007; 45:103.
- Chaturvedi AK, Pfeiffer RM, Chang L, et al. Elevated risk of lung cancer among people with AIDS. AIDS 2007; 21:207.
- D'Jaen GA, Pantanowitz L, Bower M, et al. Human immunodeficiency virus-associated primary lung cancer in the era of highly active antiretroviral therapy: a multi-institutional collaboration. Clin Lung Cancer 2010; 11:396.
- Rengan R, Mitra N, Liao K, et al. Effect of HIV on survival in patients with non-small-cell lung cancer in the era of highly active antiretroviral therapy: a population-based study. Lancet Oncol 2012; 13:1203.
- Purgina B, Pantanowitz L, Seethala RR. A Review of Carcinomas Arising in the Head and Neck Region in HIV-Positive Patients. Patholog Res Int 2011; 2011:469150.
- Roland JT Jr, Rothstein SG, Mittal KR, Perksy MS. Squamous cell carcinoma in HIV-positive patients under age 45. Laryngoscope 1993; 103:509.
- Singh B, Sabin S, Rofim O, et al. Alterations in head and neck cancer occurring in HIV-infected patients--results of a pilot, longitudinal, prospective study. ActaOncol 1999; 38:1047.
- Silverberg MJ, Leyden W, Warton EM, et al. HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer. J Natl Cancer Inst 2013; 105:350.
- Wilkins K, Turner R, Dolev JC, et al. Cutaneous malignancy and human immunodeficiency virus disease. J Am AcadDermatol 2006; 54:189.
- Neves-Motta R, Ferry FR, Basílio-de-Oliveira CA, et al. Highly aggressive squamous cell carcinoma in an HIV-infected patient. Rev Soc Bras Med Trop 2004; 37:496.
- Hoffmann C, Horst HA, Weichenthal M, Hauschild A. Malignant melanoma and HIV infection -- aggressive course despite immune reconstitution. Onkologie 2005; 28:35.
- Shields CL, Ramasubramanian A, Mellen PL, Shields JA. Conjunctival squamous cell carcinoma arising in immunosuppressed patients (organ transplant, human immunodeficiency virus infection). Ophthalmology 2011; 118:2133.
- Chisi SK, Kollmann MK, Karimurio J. Conjunctival squamous cell carcinoma in patients with human immunodeficiency virus infection seen at two hospitals in Kenya. East Afr Med J 2006; 83:267.
- Makupa II, Swai B, Makupa WU, et al. Clinical factors associated with malignancy and HIV status in patients with ocular surface squamous neoplasia at Kilimanjaro Christian Medical Centre, Tanzania. Br J Ophthalmol 2012; 96:482.
- Guech-Ongey M, Engels EA, Goedert JJ, et al. Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States. Int J Cancer 2008; 122:2590.
- Ateenyi-Agaba C, Franceschi S, Wabwire-Mangen F, et al. Human papillomavirus infection and squamous cell carcinoma of the conjunctiva. Br J Cancer 2010; 102:262.
- Moubayed P, Mwakyoma H, Schneider DT. High frequency of human papillomavirus 6/11, 16, and 18 infections in precancerous lesions and squamous cell carcinoma of the conjunctiva in subtropical Tanzania. Am J ClinPathol 2004; 122:938.
- Newton R, Ferlay J, Reeves G, et al. Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye. Lancet 1996; 347:1450.
- Timm A, Stropahl G, Schittkowski M, et al. [Association of malignant tumors of the conjunctiva and HIV infection in Kinshasa (D. R. Congo). First results]. Ophthalm-ologe 2004; 101:1011.
- De Silva DJ, Tumuluri K, Joshi N. Conjunctival squamous cell carcinoma: atypical presentation of HIV. Clin Experiment Ophthalmol 2005; 33:419.
- Cervantes G, Rodríguez AA Jr, Leal AG. Squamous cell carcinoma of the conjunctiva: clinicopathological features in 287 cases. Can J Ophthalmol 2002; 37:14.
- Basti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea 2003; 22:687.
- Gichuhi S, Irlam JJ. Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals. Cochrane Database Syst Rev 2007; :CD005643.
- Barbazetto IA, Lee TC, Abramson DH. Treatment of conjunctival squamous cell carcinoma with photodynamic therapy. Am J Ophthalmol 2004; 138:183.
- Prabhasawat P, Tarinvorakup P, Tesavibul N, et al. Topical 0.002% mitomycin C for the treatment of conjunctival-corneal intraepithelial neoplasia and squamous cell carcinoma. Cornea 2005; 24:443.
- Sturges A, Butt AL, Lai JE, Chodosh J. Topical interferon or surgical excision for the management of primary ocular surface squamous neoplasia. Ophthalmology 2008; 115:1297.
- Holkar S, Mudhar HS, Jain A, et al. Regression of invasive conjunctival squamous carcinoma in an HIV-positive patient on antiretroviral therapy. Int J STD AIDS 2005; 16:782.
- Engels EA, Frisch M, Goedert JJ, et al. Merkel cell carcinoma and HIV infection. Lancet 2002; 359:497.
- Lanoy E, Dores GM, Madeleine MM, et al. Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS 2009; 23:385.
- Wieland U, Kreuter A. Merkel cell polyomavirus infection and Merkel cell carcinoma in HIV-positive individuals. CurrOpinOncol 2011; 23:488.
- Wieland U, Silling S, Scola N, et al. Merkel cell polyomavirus infection in HIV-positive men. Arch Dermatol 2011; 147:401.
- Pantanowitz L, García-Caballero T, Dezube BJ. Growth hormone receptor (GH)-expressing carcinoid tumors after recombinant human GH therapy for human immunodeficiency virus-related lipodystrophy. Clin Infect Dis 2003; 36:370.
- Coleman H, Kennedy M, Altini M, et al. Neuroendocrine (carcinoid) tumor of the mandible: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1996; 81:74.
- Lito P, Pantanowitz L, Marotti J, et al. Gastroenteropancreatic neuroendocrine tumors in patients with HIV infection: a trans-Atlantic series. Am J Med Sci 2009; 337:1.
- Gewurz BE, Dezube BJ, Pantanowitz L. HIV and the breast. AIDS Read 2005; 15:392.
- Oluwole SF, Ali AO, Shafaee Z, DePaz HA. Breast cancer in women with HIV/AIDS: report of five cases with a review of the literature. J SurgOncol 2005; 89:23.
- Bini EJ, Park J, Francois F. Use of flexible sigmoidoscopy to screen for colorectal cancer in HIV-infected patients 50 years of age and older. Arch Intern Med 2006; 166:1626.
- Yegüez JF, Martinez SA, Sands DR, et al. Colorectal malignancies in HIV-positive patients. Am Surg 2003; 69:981.
- Chapman C, Aboulafia DM, Dezube BJ, Pantanowitz L. Human immunodeficiency virus-associated adenocarcinoma of the colon: clinicopathologic findings and outcome. Clin Colorectal Cancer 2009; 8:215.
- Persson EC, Shiels MS, Dawsey SM, et al. Increased risk of stomach and esophageal malignancies in people with AIDS. Gastroenterology 2012; 143:943.
- Pantanowitz L, Bohac G, Cooley TP, et al. Human immunodeficiency virus-associated prostate cancer: clinicopathological findings and outcome in a multi-institutional study. BJU Int 2008; 101:1519.
- Furco A, Bani-Sadr F, Guymar S, Molina JM. [Metastatic cancer of the prostate in a young 40 year-old HIV-infected male patient]. Presse Med 2003; 32:930.
- Manfredi R, Fulgaro C, Sabbatani S, et al. Disseminated, lethal prostate cancer during human immunodeficiency virus infection presenting with non-specific features. Open questions for urologists, oncologists, and infectious disease specialists. Cancer Detect Prev 2006; 30:20.
- Levinson A, Nagler EA, Lowe FC. Approach to management of clinically localized prostate cancer in patients with human immunodeficiency virus. Urology 2005; 65:91.
- Huang WC, Kwon EO, Scardino PT, Eastham JA. Radical prostatectomy in patients infected with human immunodeficiency virus. BJU Int 2006; 98:303.
- Ng T, Stein NF, Kaminetsky J, et al. Preliminary results of radiation therapy for prostate cancer in human immunodeficiency virus-positive patients. Urology 2008; 72:1135.
- Wosnitzer MS, Lowe FC. Management of prostate cancer in HIV-positive patients. Nat Rev Urol 2010; 7:348.
- Hentrich MU, Brack NG, Schmid P, et al. Testicular germ cell tumors in patients with human immunodeficiency virus infection. Cancer 1996; 77:2109.
- Lyter DW, Bryant J, Thackeray R, et al. Incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men. J Clin Oncol 1995; 13:2540.
- Powles T, Bower M, Daugaard G, et al. Multicenter study of human immunodeficiency virus-related germ cell tumors. J ClinOncol 2003; 21:1922.
- Bernardi D, Salvioni R, Vaccher E, et al. Testicular germ cell tumors and human immunodeficiency virus infection: a report of 26 cases. Italian Cooperative Group on AIDS and Tumors. J ClinOncol 1995; 13:2705.
- Fizazi K, Amato RJ, Beuzeboc P, et al. Germ cell tumors in patients infected by the human immunodeficiency virus. Cancer 2001; 92:1460.
- Powles T, Bower M, Shamash J, et al. Outcome of patients with HIV-related germ cell tumours: a case-control study. Br J Cancer 2004; 90:1526.
- Gaughan EM, Dezube BJ, Aboulafia D, et al. Human immunodeficiency virus--associated renal cell carcinoma: a transatlantic case series. ClinGenitourin Cancer 2008; 6:86.
- Bhatia K, Shiels MS, Berg A, Engels EA. Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpreta-tions from a systematic literature review. CurrOpinOncol 2012; 24:537.
- Jenson HB. Review: Epstein-Barr virus-associated smooth muscle tumors. ClinAdvHematolOncol 2010; 8:426.
- Purgina B, Rao UN, Miettinen M, Pantanowitz L. AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. Patholog Res Int 2011; 2011:561548.
- Tayib S, van Wijk L, Denny L. Gestational trophoblastic neoplasia and human immunodeficiency virus infection: a 10-year review. Int J Gynecol Cancer 2011; 21:1684.
- Moodley M, Budhram S, Connolly C. Profile of mortality among women with gestational trophoblastic disease infected with the human immunodeficiency virus (HIV): argument for a new poor prognostic factor. Int J Gynecol Cancer 2009; 19:289.
