Abstract
Purpose: Aim of our study is the evaluation of CT perfusion parameters in lung cancers according to their histopatholgical subtypes, size, location and necrosis.
Method and Materials: We performed CT perfusion in 28 patients of lung cancers on 128 slice CT scanners and calculated blood flow (BF), blood volume (BV), permeability (PMB) and mean transit time (MTT).
Statistical Analysis: Depending on the distribution of data, unpaired t-test and Mann Whitney U test were used to compare CT perfusion parameters of lung cancers. P value <0.05 was accepted statistically significant.
Results: Histology revealed squamous cell cancer (SCC) in 16 patients, adenocarcinoma (Adeno) in 10 patients and small cell lung cancer (SCLC) in 2 patients. We found that BF and PMB were significantly higher in Adenocarinoma than SCC (p <0.05). BV and MTT were not significantly differ according to lung cancer subtypes (p>0.05). Tumour of less than 3 cm in size showed significantly higher BF and PMB than tumour size greater than 3 cm (p<0.05). CT perfusion parameters were not significantly differ according lung cancer location (central versus peripheral and upper lobe versus lower lobe). BF, PMB and MTT were found significantly different between non-necrotic tumour and necrotic tumour (p<0.05).
Conclusions: In conclusion, CT perfusion parameters of lung cancer using 128-multi-detector row CT could reflects the underlying extent of tumour angiogenesis in relation to lung cancer subtypes, size and necrosis.
Keywords: Lung cancer, perfusion CT, Tumour angiogenesis.
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Corresponding Author
Dr Aniket Mondal, MD, DNB (Radiodiagnosis)
Senior Resident, Department of Radiodiagnosis, Maulana Azad Medical College, New Delhi -110002, India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile no- 09654089503
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.114
