Abstract
Background & Aim: Cisatracurium, an isomer of atracurium is a non-depolarising neuromuscular blocking drug of intermediate duration. It is devoid of histamine release when compared to atracurium. Both drug are used in liver and kidney failure. However, 2× ED95 dose of cisatracurium may not provide satisfactory intubating condition. The objective of this study was to evaluate the intubating condition, duration of action, hemodynamic effects and any adverse effects of atracurium with different doses of cisatracurium.
Methods: The study was designed as randomized controlled trial in which we compared atracurium (0.5mg/kg) and different doses of cisatracurium (0.1mg/kg and 0.15mg/kg) for intubation. Sixty patients were randomly assigned to one of three groups, group A received 0.5mg/kg of atracurium, group C1 received 0.1mg/kg of cisatracurium, and group C2 received 0.15mg/kg of cisatracurium. Onset time, duration of action, condition of intubation, hemodynamic effects, and signs of histamine release were recorded.
Results: Onset time was found to be significantly lower with group C2 compared to group C1 and group A. At the same time, 0.15mg/kg cisatracurium produced longer duration of action compared to 0.5mg/kg atracurium and 0.1mg/kg cisatracurium.
Conclusion: 0.15mg/kg cisatracurium can provide more effective, more rapid neuromuscular blocking with longer duration of action, stable hemodynamic status without any associated signs of histamine release.
Keywords: Cisatracurium, Atracurium,Hemodynamic , Histamine.
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Corresponding Author
Dr Chitta Ranjan Sarangi
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile no-9437031992
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.17
