Title: Evaluation of Effective Insulin Preparations for Glycemic control among type II Diabetes patients in a Tertiary Care Hospital
Authors: Dr Chinnusamy K, Thangamani S, Simi Joju K
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.101
Abstract
Introduction: The intensification of diabetes treatment that is, the transition from oral antidiabetic drugs to injectable treatments such as insulin is often delayed in many patients, which substantially increases the risk of diabetes-related complications. Therefore, in the present study, we evaluated the clinical effectiveness of different types of insulin preparations in patients with type II diabetes for glycemic control.
Methodology: Prospective Observational Study and it was conducted in the outpatient department of General Medicine, Karuna Medical College Hospital Palakkad in the duration of six months (November 2017 to April 2018). Patients with T2DM and treated with either Insulin Glargine or Premixed insulin preparations (70% NPH/ 30% RI, 50% NPH/50% RI or NPH or lispro and apart in a ratio of 70/30 or 75/25) using pen injector or insulin syringe were included and Baseline and after three months (Review) FBS, PPBS, RBS, HbA1c values were recorded.
Results and Discussion: After 3 months (Review I), PHI group reached statistically significant reduction on FBS (P=0.0001***), PPBS (P=0.0001***) and HbA1c (P=0.0004***). PIA group reached statistically significant small reduction on FBS (P=0.0565*), RBS (P=0.0366*), PPBS (P=0.0177*) as compared than PHI group. GLA group reached statistically significant reduction on FBS (P=0.0048**) and PPBS (P=0.0009***) only and there was no significant reduction of HbA1c.
Conclusion: Insulin Glargine and Premixed Insulin Analogues with or without OHAs are less effective insulin preparations when compared with Premixed Human Insulin (significant reduction in FBS (mg/dL), PPBS (mg/dL), and HbA1c (%)) for patients with T2DM who were inadequately controlled with OHAs.
Keywords: Insulin, Type II diabetes, Glycemic Control.
