Abstract
Introduction
Peripheral giant cell granuloma (PGCG) is a localized, benign, sometimes aggressive hyperplastic reactive lesion of oral cavity. Jaffe in 1953 proposed the term“giant-cell reparative granuloma” for such lesions occurring in the jaws while Berner & Cahn in 1954 used the term “peripheral giant cell reparative granuloma” for the peripheral lesions1,2. They believed that these lesions were not neoplasms but represented as a local reparative reaction. But as the clinical behavior of most of these lesions have been inconsistent with the reparative process, thus this nomenclature has been omitted these days.
PGCG is thought to originate from the interdental tissue (periosteum or periodontal ligament) following local irritation. Periodontal disease with varying amount of subgingival plaque and calculus too act as an important local irritant factor2,3,4. Rapidly Progressing Periodontitis (RPP) is usually seen in young adults with a female predilection.It is a multifactorial disease and mixed factors as oral flora, immunological response of patient and environment decide the severity, course and onset of the disease5,6,7.
We present here a case and management of a young female suffering from Rapidly Progressing Periodontitis with complete destruction of the alveolar bone in both the jaws with a huge PGCG in left mandibular body region.
References
- Jaffe HL. Giant cell reparative granuloma, traumatic bone cyst, and fibrous(fibrous osseous) dysplasia of the jaw bones. Oral surg Oral med Oral pathol 1953; 6: 159-175.
- Bernier JL and Cahn LR: Peripheral giant cell reparative granuloma. JADA 1954: 49;141-148.
- Lester SR ,Cordel KG, Rosebush MS, Palaiologou AA, ManeyP.Peripheral giant cell granulomas: a series of 279 cases. Oral surg Oral med Oral pathol Oral radiol 2014; 118: 475-482.
- Motamedi MHK, Jafari SM, Lassemi E, Abbas FM, Khalifeh S, Eshkevari PS. Peripheral and giant cell granulomas of the jaws: A demographic study. Oral surg Oral med Oral pathol Oral radiolEndol 2007; 103:e39-e43.
- Page RC, Altman LC, Ebersole JL, Vandesteen GE, Dahlberg WH, Williams BL, Osterberg SK. Rapidly Progressive Periodontitis. A distinct clinical condition.J Periodontal April 1983: 197-209.
- Kamma JJ, Nakou M, Manti FA. Microbiota of Rapidly Progressive Periodontitis Lesions in association with clinical parameters. J Periodontol Nov 1994. 1073-1078.
- Palcanis KG, Wolfe B, McClung JF, Elzay RP. Rapdily Progressive Periodontitis: J Periodontol June 1986, 378-382.
- Gharbyan AZ, Assaf M. Management of a Peripheral Giant cell granuloma in the esthetic area of upper jaw: A case report. International Journal of Surgery Case reports 5(2014) 779-782.
- Cooke BED. Giant cell epulis: Histogenesis and natural history. Br Dent J.1952: 93: 12-16.
- Ahmed WS. Efficacy of ethanolamine oleatesclerotherapyin treatment of peripheral giant cell granuloma. J Oral Maxillofac : 1-7, 2016.
- Katsikeris N, Angelopoulou KA, Angelopoulos AP. Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases.Int J. Oral Maxillofac Surg.1988; 17:94-99.
- Wood NK, Goaz PW: Differential diagnosis of oral and maxillofacial lesions (ed5). St Louis, MO, Mosby, 1997,141-143.
- Choi C, Terzian E, Schneider R, Trochessel DA. Peripheral giant cell granuloma associated with hyperthyroidism secondary to end stage renal disease: A case report. J Oral MaxillofacSurg 66: 1063-1066,2008.
- Chaparro AV, Berini AL, Escado G: Peripheral giant cell granuloma: A report of 5 cases and review of literature. Med Oral Pathol Oral Cir Bucal 10: 48, 2005.
Corresponding Author
Dr Gurpreet Singh Saini
Oral and Maxillofacial Surgery, SGRD, Amritsar
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.09
