Abstract
Background: Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) in T2DM subjects.
Aim: To assess the serum levels of 25-Hydroxy Vitamin D and HbA1c as well as to study the correlation of these parameters in Known Patients of type 2 Diabetes Mellitus.
Material and Methods: This hospital-based study was conducted on 45 diagnosed type 2 Diabetes mellitus patients and 25 non-diabetic age and gender matched controls .Blood sample were collected in plain vial as well as EDTA vial and serum 25-hydroxy vitamin D levels and HbA1c were evaluated. Results were collected and analyses statically.
Results: Vitamin D deficiency was seen in 35.6% and 32.6% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c in Type 2 Diabetes Mellitus patients with r value of -0.171 and -0.237 in study and control group respectively.
Conclusion: Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation could not be established.
Keywords: Diabetes, Vitamin D, HbA1c.
References
- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009;32:62–7.
- IDF: One adult in ten will have diabetes by 2030. IDF Press release; 2011 [http://www.idf.org/media events/press-releases/2011/diabetes-atlas-5th-edition], accessed on 29th August 2014.
- Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in non diabetic adults. Diabetes Care. 2007;30(4):980–6.
- Pittas AG, Dawson-Hughes B. Vitamin D and Diabetes. J Steroid Biochem Mol Biol. 2010;121(1,2):425–9.
- Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose Homeostasis. Int J Endocrinol. 2010;2010:351–85.
- Heshmat R, Malazy OT, Ahranjani SA, Shahbazi S, Khooshehchin G, Bandarian F, et al. Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial. DARU J Pharm Sci. 2012;20:10.doi:10.1186/2008-2231-20-10.
- Talaei A, Mohamadi M, Adgi Z. The effect of vitamin D on insulin resistance in patients with type 2 diabetes. Diabetol Metabol Syndr. 2013;5:8. doi:10.1186/1758-5996-5-8.
- Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell function. Am J Clin Nutr. 2004;79:820–5.
- Pittas A, Lau J, Hu F, Dawson-Hughes B. Review: the role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92:2017–29.
- Luo C, Wong J, Brown M, Hooper M, Molyneaux L, Yue DK. Hypovitaminosis D in Chinese type 2 diabetes: Lack of impact on clinical metabolic status and biomarkers of cellular inflammation. Diab Vasc Dis Res. 2009;6:194–209.
- Ritu G, Ajay G. Vitamin D Deficiency in India: Prevalence, Causalities and Interventions. Nutrients. 2014;6:729–75.
- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.
- Harinarayan CV, Holick MF, Prasad UV. Vitamin D status and sun exposure in India. Dermato-Endocrinol. 2013;5(1): 130–41.
- Harinarayan CV, Joshi SR. Vitamin D status in India-Its implications and Remedial Measures. J Assoc Physicians India. 2009;57:40–8.
- Lo CW, Paris PW, Holick MF. Indian and Pakistani immigrants have the same capacity as Caucasians to produce vitamin D in response to ultraviolet irradiation. Am J Clin Nutr. 1986;44:683–5.
- Melville NA. Large Review Casts Cloud Over Vitamin-D Health Benefits. Medscape Medical News. Dec 05, 2013. [http://www.medscape.com/viewarticle/ 815472], accessed on 27th August 2014.
- McGill AT, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J. 2008;7:4. doi:10.1186/1475-2891-7-4.
- Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care. 2006;29:2244–6.
Corresponding Author
Dr Tejinder Singh
Department of Biochemistry, Government Medical College, Amritsar
DOI: https://dx.doi.org/10.18535/jmscr/v6i4.146
