Abstract
Background: High-sensitivity C-reactive protein (hs-CRP) is known as a marker for low-grade inflammation and atherosclerosis. Due to its cardiovascular risk owing to atherosclerosis, its possible correlation with obesity in a local population was assessed, using BMI as the parameter.
Objective: To study correlation of hs-CRP with BMI in a population of 25-45 years in Alappuzha, Kerala.
Materials & Methods/Procedure: 111 subjects of either sex, with no history of coronary artery disease, ongoing systemic illnesses or steroid treatment, were selected; BMI and serum fasting levels of hs-CRP taken; arbitrarily divided into three groups, having hs-CRP levels (i)<1 mg/l, (ii)1-3 mg/l, and (iii)>3 mg/l, and the Mean BMI in each group calculated.
Results: There was significant association between BMI and hs-CRP in both males (F= 13.53;p<0.01) and females(F=15.01;p<0.01). Correlation between the same parameters indicated that there was positive correlation (r=0.054;p<0.01).
Conclusions/Implications: Further, longitudinal studies can done to estimate the role of dietary factors and chronic effect of anti-inflammatory medications on hs-CRP and BMI respectively.
Keywords:High Sensitivity C-Reactive Protein, Body Mass Index, Atherosclerosis, Coronary Artery Disease
References
- Yang SP, Gong CX, Cao BY, Yan C. Relationship between serum high-sensitivity C-reactive protein and obesity and impaired glycose metabolism in children and adolescents. Zhonghua Er Ke Za Zhi. 2006;44(12):933–936.
- Barbosa MC, Brandão AA, Pozzan R, Magalhães ME, Campana EM, Fonseca FL, Pizzi OL, Freitas EV, Brandão AP.Association between uric acid and cardiovascular risk variables in a non-hospitalized population. Arq Bras Cardiol.2011 Mar;96(3):212-8.
- Abdullah AR, Hasan HA, Raigangar VL.Analysis of the relationship of leptin, high-sensitivity C-reactive protein, adiponectin, insulin, and uric acid to metabolic syndrome in lean, overweight, and obese young females. Metab Syndr Relat Disord.2009 Feb;7(1):17-22.
- Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. "Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization". N. Engl. J. Med. September 2004;351(13):1296–1305.
- Graham L., Atar D., Borch-Johnsen K., Boysen G., Burell G., Cifkova R., et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Circulation. 2004;109:2818–2825.
- Oda E., Kawai R. Tentative cut point of high-sensitivity C-reactive protein for a component of metabolic syndrome in Japanese. Circ. J. 2009;73:755–759.
- Neogi, T., Terkeltaub, R., Ellison, R.C., Hunt, S., and Zhang, Y. Serum urate is not associated with coronary artery calcification: the NHLBI Family Heart Study. J Rheumatol. 2011; 38: 111–117
- Krishnan, E., Pandya, B.J., Chung, L., and Dabbous O. Hyperuricemia and the risk for subclinical coronary atherosclerosis—data from a prospective observational cohort study. Arthritis Res Ther.2011; 13: R66
- Keys, Ancel; Fidanza, Flaminio; Karvonen, Martti J.; Kimura, Noboru; Taylor, Henry L. "Indices of relative weight and obesity". Journal of Chronic Diseases.1972;25 (6–7): 329–43.
- Aronson, P. Bartha, O. Zinder, A. Kerner, E. Shitman, W. Markiewicz et al. Association between fasting glucose and C-reactive protein in middle-aged subjects. Diabetic Medicine- Online Open; 2004 Jan; 21(1); 39–44.
- Grunwald T., Fadia S. Bernstein B. et al. Vitamin D supplementation, the Metabolic Syndrome and Oxidative Stress in Obese Children.; J Pediatr Endocrine Metab.; 2017 Apr 1;30(4):383-388.
- Kawai VK, Avalos I, C. Michael Stein, et al. Suboptimal inhibition of platelet cyclo-oxygenase-1(COX-1) by aspirin in lupus erythematosus: Association with metabolic syndrome. Arthritis Care Res (Hoboken). 2014 Feb;66(2):285-92.
- Mohan IK, Das UN. Oxidant Stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. Prostaglandins Leukot Essent Fatty Acids. 1997 Mar;56(3):193-8.
Corresponding Author
Dr Sunayana Mathew
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DOI: https://dx.doi.org/10.18535/jmscr/v6i4.141
