Abstract
There are several natural occurring antioxidants in our body which serve to counteract against free radicals generated in our body as byproducts of various metabolic reactions. Any deficiency of these antioxidant in body would lead to increased free radical damage at cellular level which may contribute to mutations leading to oncogenesis. Majority of cancers have been shown to have some imbalance in antioxidants levels. Free radicals- antioxidant imbalance, if proven, may highlight the importance of antioxidant supplementation in prevention and as an adjunct to treatment of cancer. Here we attempt to study antioxidant enzymes namely- superoxide Dismutase, Catalase and Glutathione peroxidase, level in breast cancer patients to find any association with cancer.
Keywords: Breast cancer, Antioxidants, free radicals, Superoxide Dismutase, Catalase, Glutathione peroxidase.
References
- Malvia S., Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol. 2017; 13(4):289-295
- Fact Sheets by Cancer. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
- Oberley TD1, Oberley LW. Antioxidant enzyme levels in cancer. Histol Histopathol.1997 Apr;12(2):525-35.
- McCord J., Fridovich I. Superoxide dismutase- an enzymic function for erythrocuprein (hemocuprein). The Journal of Biological Chemistry 1969; 244: 6049-6055
- Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6
- Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967, 70(1):158.
- Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease[J]. Int J Biochem Cell Biol 2007; 39: 44–84.
- Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research [J]. J Nutr 2003; 133: 933S–40S.
- Bagchi K, Puri S. Free radicals and antioxidants in health and disease[J]. Eastern Mediterranean Health Journal 1998; 4: 350–360.
- Champe PC, Harvey RA, Ferrier DR. Intermediary metabolism. Champe PC, Lippincott’s Illustrated Reviews: Biochemistry. 4th edition[M]. Lippincott Williams & Wilkins. Philadelphia, USA. 2007; p: 69–82, 148.
- Prabasheela B. Association between Antioxidant Enzymes and Breast Cancer. Recent Research in Science and Technology 2011, 3(11): 93-95 ISSN: 2076-5061
- Polat FM, Taysi S, Gul M, Cikmano, Yilnaz I, Bakan E. Oxidant/antioxidant status in blood of patients with malignant breast tumour and benign breast disease. Cell biochem Funct.2002;20:327-331.
- Sinha RJ, Singh R, Mehrotra S, Singh RK. Implications of free radicals and antioxidant levels in carcinoma of the breast: A never-ending battle for survival. Indian J Cancer 2009; 46:146-50
- Pawlowicz Z., Zachara BA, Trafikowska U. et al. Blood selenium concentrations and glutathione peroxidase activities in patients with breast cancer and with advanced gastrointestinal cancer. Trace Elem Electrolytes Health Dis.1991 Dec;5(4):275-7
- Yeldu et al. Lipid Peroxidation and Enzymatic Antioxidants among Breast Cancer Women of African Descent in Sokoto, Nigeria ; Annual Research & Review in Biology. 2017;14(3):1-8
- Khanzode S.S., Muddeshwar M.G., Khanzode S.D. and Dakhale G.N.: Antioxidant enzymes and lipid peroxidation in different stages of breast cancer. Free Radic. Res., 38: 81-5, 2004.
- Gibananda R., Batra S., Shukla NK, Deo S., Raina V., Ashok S, Husain SA. Lipid peroxidation, free radical production and antioxidant status in breast cancer. Breast Cancer Research and Treatment. 2000;59(2):163-170
Corresponding Author
Parijat Suryavanshi
Department of General Surgery,
King George’s Medical University, Lucknow, India
DOI: https://dx.doi.org/10.18535/jmscr/v6i4.98
