Abstract
Background: Sickle cell disease has been reported from all over the world including India. The early detection of sickle cell nephropathy & its treatment is essential for improving quality of life in these children.
Objective: Current study aims at to study the features of renal involvement in sickle cell disease patients.
Materials & Method: 81 consecutive cases admitted to hospital with sickle cell disease were studied by history, thorough examination & stepwise investigations including urine routine examination, culture-sensitivity & concentration test; Blood urea and serum creatinine.
Results: The mild proteinuria, microscopic hematuria, pyuria and casts had been noted in 19.5% (16 cases), 14.8% (12 cases), 19.5% (16 cases) and 4.9% (4 cases) of sickle cell disease patients respectively. The concentrating capacity of the tubules was significantly affected in children with sickle cell disease in elderly age groups. But no significant changes were observed in the younger children, in the age group of 2 to 5 years.
Conclusion: There is a significant impairment in concentrating capacity of kidney with increasing age among sickle cell disease patients but no difference in earlier age group.
Keywords: Sickle cell nephropathy, hyposthenuria.
References
- http://timesofindia.indiatimes.com/city/ranchi/10-of-tribals-afflicted - with - sickle – cell anaemia / articleshow / 48037811.cms.
- Alleyne GAO, Statius Van EPS LW, Addoc SK, Nicholson GD 8s schonten H. The kidney in sickle cell anaemia (editorial review) Kidney Int 1975; 7: 371-379.
- Lucas, W. M. and Bullock, W. H. Hematuria in sickle cell disease. J. Urol. 1960;83: 733.
- Perrine RP, Pembrey Me et al. Natural History of Sickle Cell Anemia in Saudi Arabs; A Study of 270 Subjects. Ann Intern Med 1978; 88:1-6.
- Statius Van EPS LW, Schonten H, TEr Harr. Romeny Warchter CCH & La Porte-Wijsman LW. The relationship between age and renal concentrating capacity in sickle cell disease and hemoglobin C disease. Clin Chin Acta 1970; 27 : 501-511.
- Chaubey BS, Waiker SM, Shivde AV, Grover S.J Assoc Physicians India. 1975 Mar;23(3):171-7. No abstract available.
- Konotey-Ahulu, The Sickle Cell Diseases Clinical Manifestations Including the "Sickle Crisis" Arch Intern Med. 1974;133 (4):611-619.
- Bauer, J. : Sickle cell disease, Arch, surg. 41 : 1344 (Dec.) 1940.
- Hatch, James W. Culbertson, and Lemuel W. Diggs ,Nature of the Renal Concentrating Defect in Sickle Cell Disease 1967 Mar; 46(3): 336–345.
- Buckalew, VM, Someren, A. Renal manifestations of sickle cell disease. Arch Intern Med. 1974; 133 : 660.
- Kokko JP, Rector FC. Countercurrent multiplication system without active transport in inner medulla. Kidney Int. 1972;2:214–223.
- Jamison R, Buerkert J, Lacy FB: A micropuncture study of Henle's thin loop in Brattleboro rats. Am J Physiol. 1973; 224:180—185.
- Etteldorf, J. N., Smith, J. D., Tuttle, A. H. & Diggs, L. W. Renal hemodynamic studies in adults with sickle cell anemia. J. Med.1955;18, 243–248.
- Morgan AG & Serjeant GR. Renal function in patients over 40 with homozygous sickle-cell disease. British Medical Journal.1981; 282: 1181-1183.
- Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A . "A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine". Pediatrics. 1976 ,Aug;58 (2): 259–63.
Corresponding Author
Dilip Kumar
Junior resident, Department of Pediatrics and Neonatology, RIMS, Ranchi
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile no: 7070434160
DOI: https://dx.doi.org/10.18535/jmscr/v6i4.54
