Abstract
Non melanoma skin cancers (NMSC) are the most common malignant tumors in humans, with Squamous cell carcinoma(SCC) constituting about one-fourth of these cases.Considering that patients with vitiligo have no protective pigment (melanin) in sun-exposed depigmented skin, it would be expected that these patients develop a higher risk for photodamage and NMSC. However, there is a paucity of reports of NMSC in sun exposed, long standing vitiliginous skin as NMSC are rare occurrences in such patients. Currently, ablative surgery is almost always recommended as the treatment for most SCCs. Nonetheless, High dose rate (HDR) surface mould brachytherapy is a safe and simple alternative to surgery, in selected cases, as it successfully eradicates the tumor and also preserves hand function. We report a case of generalized vitiligo with cutaneous SCC of the hand treated with surface mould brachytherapy.
Keywords: Squamous cell carcinoma (SCC), long standing vitiliginous skin, High dose rate (HDR) surface mould brachytherapy.
References
- Somanchi BV, Stanton A, Webb M, Loncaster J, Allan E, Muir LTSW. Hand function after high dose rate brachytherapy for squamous cell carcinoma of the skin of the hand. Clinical oncology (2008) 20: 691-697.
- Calanchini–Postizzi E, Frenk E. Long term actmic damage in sunexposedvitiligo and normally pigmented skin. Dermatologica 1987;174:266-71.
- Hexsel CL, Eide MJ, Johson CC, Krajenta R, Jacobsen G, Hamzavi I, Lim HW. Incidence of non melanoma skin cancer in a cohort of patients with vitiligo. J Am Acad Dermatol. 2009 Jun;60(6):929-33.
- Seo SL, Kim IH. Squamous cell carcinoma in a patient with generalized vitiligo. J Am AcadDermatol. 2001 Dec;45(6 Suppl):S 227-9.
- Saarinen K, Lestringant GG, Masouye I, Frossard PM. Actinic damage and squamous cell carcinoma in sun-exposed skin affected by vitiligo. Br J Dermatol. 2000 Jul;143(1):219-21.
- Hexsel CL, Eide MJ, Johson CC, Krajenta R, Jacobsen G, Hamzavi I, Lim HW. Incidence of non melanoma skin cancer in a cohort of patients with vitiligo. J Am AcadDermatol. 2009 Jun;60(6):929-33.
- Kubaseiurcz M, Starzynski Z, Szymczak W. Case-referent study on skin cancer and its relation to occupational exposure to polycyclin aromatic hydrocarbons. II. Study results. Pol J Occup Med Environ Health 1991;4(2):141-7.
- Jarvholm B, Easton D. Models for skin tumor risks in workers exposed to mineral oils. Br J Cancer. 1990 Dec;62(6):1039-41.
- Montero A, Hernanz R,CapuzA. High-dose-rate (HDR) plesiotherapy with custom-made moulds for the treatment of non-melanoma skin cancer. ClinTranslOncol (2009) 11:760-764.
- Grootenboersa D,Poortmansa P, Haas R. Radiotherapy preserves fingers in the managementof subungual squamous cell carcinoma, obviatingthe need for amputation. Radiotherapy and Oncology 85 (2007) 473–476.
- Alam M, Nanda S, Mittal BB, Kim NA, Yoo S. The use of brachytherapy in the treatment of nonmelanoma skin cancer: a review. J Am AcadDermatol 2011; 65: 377-88.
Corresponding Author
Dr Seema Goel
Assistant Professor, Department of Dermatovenereology,
Government Medical College, Patiala, Punjab
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., 9814610676