Title: A comparative study to evaluate the effect of misoprostol for induction of labour at term by intravaginal versus sublingual route
Authors: Dr Rajkishori Dandotiya, Dr Suman Kumari, Dr M Rameswar Singh
DOI: https://dx.doi.org/10.18535/jmscr/v6i4.35
Abstract
Background: Induction of labour is defined as the process of artificial stimulation of uterine contractions before the spontaneous onset of labour. Amongst the plethora of techniques available for induction of labour, Prostaglandins remain the single most effective mean of cervical ripening and inducing labour.
Objectives: Current study was carried out to compare the efficacy of sublingual misoprostol with intravaginal misoprostol for induction of labour.
Methodology: This was a hospital based randomized prospective study conducted in the Department of Obstetrics and Gynaecology at RIMS Imphal. 462 women at term pregnancy with single live foetus having Bishop Score ≤6 who required induction of labour for various indications were enrolled and randomly allocated into two groups. Group 1 received 50mcg misoprostol vaginally while second group received same dose of misoprostol sublingually every 4-6hourly. Outcome measures related to labour and maternal and fetal side effects were compared.
Results: There was no significant difference between both groups with regards to base line characteristic , indications for induction of labour, mean interval from the initiation of induction to the delivery, neonatal outcome and maternal complications. However significant difference was observed in Bishop Score after 4 hours and requirement of oxytocin augmentation.
Conclusion: Misoprostol can be used either sublingually or by vaginal route for induction of labour at term without any major fetal and maternal side effects.
Keywords: Induction, Labour, Misoprostol, Sublingual, Vaginal.
