Title: Chorangiosis of the Placenta: Association with Maternal Profile and Neonatal Outcome, Experience at our Centre
Authors: Divya Gupta, Parminder Singh
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.186
Abstract
Chorangiosis is a vascular change of the placenta that involves the terminal chorionic villi. It has been proposed to result from longstanding, low-grade hypoxia in the placental tissue and has been associated with conditions such as pre-eclampsia, diabetes and intrauterine growth restriction (IUGR). The entity has been bracketed with adverse feto-maternal outcome. This interplay of maternal and fetal factors may combine to produce this pathologically distinct entity of clinical significance. To characterize chorangiosis with its related maternal and fetal profile, we identified 15 cases of chorangiosis at our centre.
Material and Methods: Histomorphology of 50 placentas received in a tertiary care hospital were studied for chorangiosis/ chorangiomatous lesions as per the defined criteria. Association with neonatal and maternal profile was determined.
Results: Among the 50 placentas received in a tertiary care hospital, 15 had evidence of chorangiomatosis/ chorangiosis. No Fatal outcome was present in our cases, while the associated neonatal morbidity in the form of IUGR, Low Birth Weight, prematurity and NICU admissions were high. In terms of maternal profile, strong positive association of chorangiomatous lesions with pregnancy induced hypertension/preeclampsia was noted.
Conclusion: This admonishes the pathologists to identify this entity that elucidate causes of neonatal morbidity and mortality even if they do not directly contribute to it.
Keywords: Chorangiosis, Placenta, pre-eclampsis, chorionic villi, neonatal outcome.
