Abstract
Objective: Aim of this study is to compare the conventional Pap smears with manual liquid based cervical cytology in peri menopausal and post menopausal women.
Method: A prospective study of 70 women was carried out in SGT University Hospital, Gurugram over the period of 1 year. Patients were randomly selected for pap smears and data collected was analysed.
Result: Analysis included patients aged more than 40 years. 70 cases were satisfactory for evaluation using LBC and 65 cases on conventional smear. Cytological abnormality was found in 29 cases on LBC and in 21 cases on conventional smear. Out of 70 cases 10 and 5 cases were diagnosed as ASCUS, 5 and 3 as HSIL, 12 and 8 as SCC on LBC and conventional smear respectively.
Conclusion: In conclusion, despite the smaller sample size MLBC method was found to be superior to the conventional smear.
Keywords: Conventional smear, Liquid based cytology, Bethesda.
References
- Schiffman M, Castle PE, Jeronim J, Rodrigue AC, Wacholde S. Human papillomavirus and cervical Lancet 2007;370:890–907.
- Nandini NM, Nandish SM, Pallavi P, Akshatha SK, Chandrashekhar AP, Anjali S, Dhar M. Manual Liquid Based Cytol-ogy in Primary Screening for Cervical Cancer- a Cost Effective Preposition for Scarce Resource Settings. Asian Pac J Cancer Prev. 2012;13: 3645-51.
- Kavatkar AN, Nagwanshi CA, Dabak SM. Study of a manual method of liquid-based cervical cytology. Indian J Pathol Microbiol. 2008;51:190–4.
- Strander B, Andersson-Ellstrom A, Milsom I, Radberg T, Ryd W. Liquid-based cytology versus conventional Papanicolaou smear in an organized screening program: A prospective rando-mized study. Cancer. 2007;111:285-91.
- Anderson MC,; editor. Female reprod-uctive system. Systemic Pathology, 3rd Vol. 6. London: Churchhill Livingston; 1991. P.480
- Quereshi S, Singh U, Foruin S, Negi N, Agarwal G, Singh N.Liquid based cytology vs conventional cytology as a screening tool of cervical cancer in post menopausal women. JSAFOG. 2017. 9(2): 159-163.
- Lopez-Cuervo JE, Beltran EM, Lopez JLC, Castillo AA, Sanchez TN. Preliminary Study of a New, Fully Automated System for Liquid-Based Cytology: The NovaPrep Processor System. Acta Cytol .2011;55:281-6.
- Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1999. CA Cancer J Clin. 1999;49:8–31.1
- Nayar R.Wilbur D.C. The Pap Test and Bethesda 2014. Acta Cytologica. 2015;59:121-32 .
- Chinaka CC, Abudullahi M, Mohammed OM. A Comparative Study on the Use of Liquid Based Cytology and Conventional Pap Smear in Cervical Screening. J Med Med Res. 2014;2(4):40-50.
- Shakarnarayana R, Nene BM, Dinshaw K, Raj Kumar. Early detection of cervical cancer with visual impaction methods: a summary of completed and ongoing studies in India. Shawad Publica de Mexico. 2003;45:291-301.
- Parker DM, Pisani P, Ferlay J. Cancer incidence, mortality and prevalence worldwide. Ver. 1 IARC Cancer No.5; Lyon Press. 2001.
- Kenneth DH, Yao S Fu. Cervical and vaginal cancer, Novak’s Textbook of Obstetric and Gynaecology, 13th ed. Baltimore: WB Saunders Co. 2002.p.471-93.
- Robert ME, Fu YS. Squamous cell carcinoma of the uterine cervix - a review with emphasis on prognostic factors. Semin Diagn Pathol. 1990;7:173-89.
- Sherwani RK, Khan T, Akhtar K, Zeba A, Siddiqui FA, Rahman K, Afsan N. Conventional Pap Smear and Liquid Based Cytology for Cervical Cancer Screening- A Comparative Study. J Cytol. 2007;24:167-72.
- Coste J, Priollet B C, Cremoux P D, Galès C L, Cartier I, Molinié V, Labbé S , Lavenu M C V, Vielh P. Cross sectional study of conventional cervical smear, monolayer cytology, and human papillomavirus DNA testing for cervical cancer screening. 2003;326 (7392):733.
- Cheung AN, Szeto EF, Leung BS, Khoo US, Ng AW. Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population. Cancer. 2003;99:331–35.
- Maksem JA, Finnomore M, Belsheim BL, Roose E.B, Makkapati S.R, Eatwell L, Weidmann J. Manual method for liquid based cytology. A demonstration using 1,000 Gynaecological cytologies collected directly to vial and prepared by a smear – slide technique. Diagn Cytopathol. 2001;25: 334-8.
- Bolick DR, Hellman DT. Laboratory implementation and efficacy assessment of the thin prep cervical cancer screening system. Acta Cytol. 1998;42:209-13.
- Beerman H, van Dorst EB, Kuenen-Boumeester V, Hogendoorn PC. Superior performance of liquid-based versus conventional cytology in a population –based cervical cancer screening program. Gynecol Oncol. 2009;112:572-76.
Corresponding Author
Dr Pooja Khari
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DOI: https://dx.doi.org/10.18535/jmscr/v6i2.178
