Abstract
An infant aged 18 days had trisomy of chromosome 21 along with pericentric inversion of Y chromosome. He failed to develop. Later, he died. Herewith, we report a case of chromosome 21 trisomy with percentric inversion of Y chromosome.
References
- Sheth FJ, Shah ushma J, Desai Manisha J, Sheth JJ. Clinical profile of inversion Y in people of Gujarat, West India. Int J Hum Genet 2011; 11 (4): 245-248.
- Arasaki DT, Sparkes RS. Microtechnique for culturing leucocytes from whole blood. Cytogenetics 1963; 2: 57-60.
- Veerbhadrappa SK, Chandrappa PR, Roodmal SY, Shetty SJ, Madhu Shankari Gunjioganur S, Mohan Kumar Kumbar P. Karyotyping: Current perspectives in diagnosis of chromosomal disorders. Sifa Med J 2016; 3: 35-40.
- Verma S, Rodriguez J, Dosik H. The clinical significance of pericentric inversion of the human Y chromosome: a rare “third” type of heteromorphism. The J of heredity 1982; 73: 236-238.
- Jacobs PA. Structural abnormalities of the Y chromosome in man. Nature 1966; 210: 352-354.
- Orye E, Verharren H. A peculiar t (21: 14) translocation, associated with a percentric inversion of the Y chromosome in mongol boy. Ann Genet 1974; 17: 217-220.
- Sparkes RS, Muller HM, Veomett IC. Inherited pericenetric inversion of a human Y chromosome in trisomic Down’s syndrome. J Med Genet 1970; 7: 59-62.
Corresponding Author
Ashok Kumar Kapoor
D87 Mahanagar Extension, Vigyan Puri, Lucknow, U.P., India
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