Abstract
Introduction: Better control of hypertension while maintaining good quality of life with least side effect has always been the aim of antihypertensive therapy. Search for newer drugs continues and azilsartan has come up with so claimed improved quality.
Aims and Objectives: To study the so claimed improved quality of azilsartanin terms of efficacy and acceptability.
Material and Method: 2 doses of azilsartan (40 & 80 mg) is compared with 40 mg of olmesartan. 111 patients enrolled from the outdoor patients of Anugrah Narayan Medical College Hospital, Gaya randomized to three groups and clinic BP measurements recorded and analysed.
Results: Azilsartan showed more reduction of both systolic and diastolic BP compared to olmesartan .Safety profile was comparable. Quality of life appears slightly better with azilsartan.
Discussion: Many clinical trials also favours its superior efficacy. Azilsartan possesses very high affinity for angiotensin type II receptor (AT I R) with characteristically slow dissociation property Azilsartan also exhibits pleotropic effect making it better for cardio vascular and reno-protection.
Conclusion: Azilsartan is a novel angiotensin receptor blocker. It exhibits all the good quality of ARB with superior efficacy.
Keywords: angiotensin receptor blocker. azilsartan .olmesartan. clinic blood pressure. Clinical trials.
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Corresponding Author
Dr P K Sinha
45, A P Colony, Gaya -823001, Bihar, India
Mobile no- 9431068999, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.17
