Title: Cytomorphological Analysis of Synovial Fluid in a Tertiary Care Hospital
Authors: Shraddha Karn, T.B.Uma Devi, Erli Amel Ivan, Ramya.G
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.125
Abstract
Synovial fluid helps to distinguish between various inflammatory, non-inflammatory, traumatic, septic and crystal induced arthritis, to the extent that it is called as the liquid biopsy of the joints. Analysis of synovial fluid is a minimal invasive technique and is vital in diagnosis and management. Inconclusive cytology reports may result from inadequate sampling to lack of ancillary studies. 72 synovial fluid samples from November 2015 to May 2017 in cytology section of Pathology Department was included in tertiary care hospital the study. Along with the routine cytological study, biochemical parameters and crystal examination with clinical correlation was done. Total of 72 cases taken in which 48 and 16 cases were acute and chronic synovitis respectively .6 cases of gout and 2 cases of rheumatoid arthritis. All cases of gout in the study showed high ESR level, thick consistency, whitish appearance and needle shape crystals. The cases with acute synovitis showed aspirates of high cellularity. Gout shows high glucose level. Proteins level were high for acute synovitis and rheumatoid arthritis Synovial fluid cytology with other biochemical , microbiological and polarized microscopy for needle examination with clinical correlation is important for detail study of synovial fluid analysis and management.
Keywords: FNAC, Synovial fluid, Macroscopic examination, Biochemical analysis, Crystal examination.
