Abstract
Background: Blood consists of plasma, erythrocytes, leucocytes and platelets. The relationship between serum levels of alkaline phosphatase (ALP), total acid phosphatase (TAP), tartrate inhibited acid phosphatase (TIAP) activities and blood groups and genotypes were studied.
Methods: By standard blood grouping and electrophoretic techniques, ABO blood groups and genotypes were determined in 113 apparently healthy male blood donors who reported at University College Hospital, Ibadan (UCH). By the use of the standard methods the activities of alkaline phosphatase, total acid phosphatase, tartrate inhibited acid phosphatase were measured respectively. Standard routine tests were also used for blood grouping and blood genotypes. Participants gave their written informed consent.
Results: The % distributions of ABO blood groups were: 21.2, 28.3, 8.8 and 41.6 for blood groups A, B, AB and O respectively. The % distributions of genotypes were: 70.8, 22.1 and 7.1 for genotypes AA, AS and AC respectively. The mean serum activity of alkaline phosphatase (K.A units/100ml) significantly increases in blood group 0>B>A>AB as thus: 12.72 ± 3.24, 11.05 ± 3.15, 9.41 ± 3.46, 9.21 ± 2.47 (f= 7.33; 0.000) respectively. The mean serum activity of total acid phosphatase (K.A units/100ml) significantly increases in blood group 0>AB>B>A as thus: 4.69 ± 1.39, 4.64 ± 1.02, 4.16 ± 0.91, 3.88 ± 1.15 (f= 2.96; 0.036 (P<0.05)) respectively. The mean serum activity of tartrate inhibited acid phosphatase was the same in the different blood groups studied (f= 0.81; 0.49 (P>0.05)) respectively. The mean serum activities of alkaline phosphatase, total acid phosphatase and tartrate inhibited acid phosphatase were the same in the different blood genotypes studied (f= 1.80; 0.17 (P>0.05)) respectively. There was a positive correlation between blood groups vs ALP, ALP vs TAP, ALP vs TIAP, TAP vs TIAP and a negative correlation between genotype AC and total acid phosphatase in blood donors.
Conclusion: Blood group O and genotype AA has the highest prevalence rate of 41.6 % and 70.8% respectively. Blood group O has the highest levels of both serum activities of ALP and total acid phosphatase respectively while blood group A has the least levels of both serum activities of ALP and total acid phosphatase respectively.
Keywords: Blood groups, genotypes, ALP, TAP, TIAP.
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Corresponding Author
I.P. Ezeugwunne
Dept of Human Biochemistry; College of Health Sciences,
Nnamdi Azikiwe University, Nnewi, Nigeria
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., +2348034096675
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.118
