Title: Granuloma Annulare and Dupuytren Contracture as First Clinical Manifestation of Diabetes Mellitus: A Case Report
Authors: Amandeep Raghuvanshi, Sujaya Manvi, Rajni Sharma
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.115
Abstract
Granuloma annulare (GA) is a relatively common idiopathic disorder of the dermis and subcutaneous tissue. The lesions typically appear as papules and plaques with annular margins most commonly on dorsal surfaces of hands, arms and feet. GA has been associated with a variety of comorbidities including diabetes mellitus. Dupuytren’s disease (DD) is a common progressive fibrotic condition affecting the palmar and digital fascia. The association of Dupuytren’s disease with diabetes mellitus (DM) is well recorded, with a reported prevalence of between 3% and 32%. Here we present a patient who presented with granuloma annulare, on examination had bilateral Dupuytren contractures and was later found to be diabetic.
Keywords- Granuloma annulare, Dupuytren’s disease, annular plaque.
References
- P, Farshchian M. Granuloma annulare: relationship to diabetes mellitus, thyroiddisorders and tuberculin skin test. Clin Cosmet Investig Dermatol. 2017; 10: 141–45.
- Saraf S. Duputren’s disease. Indian J Dermatol Venereol Leprol 2010; 76: 291-93.
- Fayyazi A, Schweyer S, Eichmeyer B, et al. Expression of IFN gamma, coexpression of TNF alpha and matrix metalloproteinases and apoptosis of T lymphocytes and macrophages in granuloma annulare. Arch Dermatol Res. 2000;292(8):384–90.
- Mempel M, Musette P, Flageul B, et al. T-cell receptor repertoire and cytokine pattern in granuloma annulare defining a particular type of cutaneous granulomatous inflammation. J Invest Dermatol.
2002;118(6):957–66. - Cyr PR. Diagnosis and Management of Granuloma Annulare. Am Fam Physician. 2006;74(10):1729-34.
- Chutorian BM, Han G, Cohen SR. Dermatological Manifestations of Diabetes Mellitus: A Review. Endocrinology and Metabolism Clinics of North America 2013: 42(4):869-99.
- Bayat A, McGrouther DA. Management of Dupuytren's disease – clear advice for an elusive condition. Ann R Coll Surg Engl 2006;88:3-8.
- Murrell GA, Hueston JT. Aetiology of Dupuytren’s contracture. Aust N Z J Surg 1990;60:247–52.
- Geoghegan JM, Forbes J, Clark DI, et al. Dupuytren’s disease risk factors. J Hand Surg [Br] 2004;29:423-6.
- Noble J, Heathcote JG, Cohen H. Diabetes mellitus in the aetiology of Dupuytren’s disease. J Bone Joint Surg 1984;66:322–5.
- Arkkila PE, Kantola IM, Viikari JS. Dupuytren’s disease: association with chronic diabetic complications. J Rheumatol 1997;24: 153–9.
- Hart MG, Hooper G. Clinical associations of Dupuytren’s disease. Postgrad Med J 2005;81:425–28.