Abstract
Individuals with diabetes mellitus, both NIDDM and IDDM are at an increased risk for cardiovascular morbidity and mortality compared to non-diabetic subjects. The cardiac dysfunction in diabetes can be broadly classified as:
- Atherosclerotic coronary heart disease
- Cardiac autonomic neuropathy
- Diabetic cardiomyopathy
In this review, we shall discuss briefly about the various mechanisms involved in cardiac dysfunction.
Atherosclerotic coronary heart disease
Diabetes in an independent risk factor for developing coronary artery disease (CAD)1. The overall prevalence of CAD is as high as 55% for adults with diabetes compared with a prevalence of 2-4% in general population. Data from Framingham Heart Study2 clearly demonstrates the increased risk and poor prognosis of, cardiac disease in diabetes. Mortality due to CAD is twice more common in diabetic men and quadrupled in diabetic women compared to their counterparts. The prevalence of angina, myocardial infarction and sudden death3 are more common in diabetics. Table 1 summarizes the quantum increase is major cardiovascular events due to CAD in diabetics compared to non-diabetics.
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Corresponding Author
Dr Santosh Kumar
Assistant Professor Deptt. of Biochemistry
Nalanda Medical College, Patna
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.100
