Abstract

Introduction

In patients with mild Psoriatic Arthritis (PsA) NSAIDs may be adequate for the relief of pain and inflammation but that do not alter the course of the disease. Non Biological DMARDs like Methotrexate (MTX), Sulfasalazine, Leflunomide and Cyclosporine when used alone or in combination help in limiting the disease progression. Choosing the best treatment in PsA has no thumb rule and response may vary from patients to patients. The drugs are employed in the more aggressive form of PsA with multiple joint involvement of axial skeleton with or without of appendicular skeleton. DMARDs work by blocking the inflammation caused by our human immune system. MTX is usually the first line drug, if this proves ineffective Leflunomide, Sulfasalazine and cyclosporine are added in the treatment regimen.