Abstract
Background: Diabetes is everywhere a most common growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. The study of plants that possess Antidiabetic activity may give a new idea in the treatment approaches of diabetes mellitus.
Objective: The present study was aimed to evaluate the antihyperglycemic effect of Aqueous extract of Carica papaya linn. Leaves (AECPL) in alloxan‑ induced diabetic albino rats.
Methods: Albino rats weighing 150- 250 grams were grouped into 6 equal groups taking 6 rats in each. Group A served as control(normal), Group B as diabetic control, Group C, D & E was receivedalloxan+ AECPL suspension at a doses of 100, 200 & 400 mg/kg orally respectively, Group F was givenalloxan + standard drug Glibenclamide (0.1mg/kg b.w.) suspension for 21 days & the AECPL effect on blood sugar was measured at regular intervals. At the end of this research study blood samples were collected from all rats for biochemical estimation.
Results: The present study revealed that the AECPL has statistically significant (P < 0.05) and sustained Antihyperglycemic effect which is comparable with the hypoglycemic effect of standard drug Glibenclamide.
Conclusion: It is concluded that the AECPL has shown significant antihyperglycemic effect at a doses of 100, 200 & 400 mg/kg. b.w. in alloxan induced diabetic albino rats.
Keywords: AECPL, Glibenclamide, Antidiabetic, Aqueous extract, albino rats, blood sugar, glucometer, herbal remedy.
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Corresponding Author
Dr Chakrapani Cheekavolu
Department of Pharmacology, Kerala Medical College and Hospital,
Mangode, Palakkad, Kerala, India,
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.187
