Abstract
The rising prevalence of obesity in India has a direct correlation with the increasing prevalence of obesity-related co-morbidities; hypertension, the metabolic syndrome, dyslipidemia, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD).
Methods: A case control study was conducted in the department of biochemistry, Osmania general hospital, Hyderabad with the objective of assessing the discriminatory power of atherogenic indices over individual lipids in risk assessment of Myocardial infarction in obese. Cases were categorized into obese and non obese MI group depending on the BMI. Control groups were selected from the outpatient department of Osmania General Hospital. Control groups were classified into healthy controls and obese controls basing on BMI.
Results: The mean values of BMI , WHR , TC , TAG, LDL-C ,CRR, AC, AIP are higher in obese controls when compared to healthy controls, HDL-C is lower in obese control group when compared to healthy control group. The BMI exhibited better discriminatory power than WHR. AIP and TAG exhibited the highest combined sensitivity and specificity followed by AC and CRR, TC and LDL-C in discriminating healthy controls and obese controls.
Conclusion: We conclude the present study showed atherogenic indices were found to be better markers in explaining the pathogenesis of atherosclerosis. Among them AIP had the highest sensitivity and specificity followed by cardiac risk ratio, atherogenic coefficient and TAG in predicting the future risk of development of atherosclerosis in obese.
Keywords: Cardiac risk ratio (CRR), atherogenic coefficient (AC) and atherogenic index of plasma (AIP). Hypertension, metabolic syndrome, dyslipidemia, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD)
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Corresponding Author
Gulam Saidunnisa Begum
Associate Professor, Department of Biochemistry,
Mahavir Institute of Medical sciences, Vikarabad, Telangana State, India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.148
