Abstract
Objectives: To Study the effect of sepsis on the platelet counts and other platelet indices in neonates.
Patient and Methods: This observational study was conducted prospectively over a period of one year from November 2014 to October 2015in neonatal division of department of Paediatrics, MMIMSR, Mullana. A total of 100 neonates, who had positive septic screen and/or positive blood culture and/or clinical features suggestive of neonatal sepsis, were included in the study and were compared with appropriately matched control of 100 healthy neonates. The complete septic workup along with indices like platelet distribution width (PDW), mean platelet volume (MPV) was also done.
Results: A total of 100 neonates were enrolled for the study (85 were with positive septic screen/culture proven and 15 were of clinical sepsis). We found that in cases mean platelet count was 1.09 lakh/mm3, mean PDW was 12.1% and MPV was 16.7fL. In control group mean platelet count was 2.70 lakh/mm3, mean PDW 10.8% and MPV was 16.3fl.Difference in these indices was statistically significant (platelet count P value .004, PDW P value < .001, and MPV P value .003). Birth weight and type of onset of sepsis had no effect on platelet indices in septic babies (platelet count P value.341, PDW .560 and MPV .452). Among sepsis cases, no significant difference was found in term and preterm babies as regard to platelet indices. Also, there is no significant effect on platelet count by the type of causative organism.
Conclusion: Low platelet counts, high mean platelet volume and platelet distribution width was observed in sepsis cases with a statistically significant difference as compared to controls.
Keywords: platelet indices, neonatal sepsis.
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Corresponding Author
Dr Baljeet Maini
Associate Professor, Pediatrics, MMIMSR, Mullana
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.138
