Abstract
Objective: To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs standard therapy alone in children with acute exacerbation of asthma.
Design: Randomized control trial.
Setting: Tertiary care Pediatric Intensive Care Unit (PICU), duration of study from October 2014 to September 2016.
Participants: Three month to twelve years with acute severe asthma (<24 hours) with initial Becker Score >7 were eligible for this study.
Interventions: The study group received NIV under inspiratory positive airway pressure ranging between 10 cm - 18 cm H2O, expiratory positive airway pressure between 4 cm - 12 cm H2O. Vital signs, PO2, PCO2, pH, SPO2 , becker score were recorded at the start, 1, 2, 4, 12, 24, and 48 hrs into the study.
Result: Heart rate after four hour and twelve hour and respiratory rate after two hour of treatment were significantly lower compared with admission (p = 0.0001 and p = 0.0294, respectively). With NIV, PO2 at four hour, SPO2 at two hour improved significantly. The endotracheal intubation was significantly lower (22%) in the NIV group than in the control group (45%; p = 0.01698).There was significant difference in length of stay in PICU (p= 0.0109) and hospital (p = 0.0115).
Conclusion: NIV seems to afford these children protection from endotracheal intubation and reduced in length of stay in PICU and hospital.
Keywords: Non Invasive Mechanical Ventilation, Asthma.
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Corresponding Author
Md Rahiul Islam
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DOI: https://dx.doi.org/10.18535/jmscr/v5i11.103
