Abstract
Introduction: Gallbladder cancer is the most common malignancy of the biliary tract, an early clinical diagnosis is enigmatic. Epidemiological studies have identified striking geographic and ethnic disparities - inordinately high occurrence in American Indians, elevated in Southeast Asia, yet quite low elsewhere in the Americas and the world.
Objective: The objective was to find out the mean age of diagnosis of Gall Bladder Carcinoma and to find out the association of the carcinoma with gender, if any.
Materials and Methods: A cross sectional observational study was conducted in Medical College and Hospital, Kolkata by Consecutive sampling method during the time period Jan 2016- Dec 2016.
Results: Out of 57 study subjects 35.08% were males and 64.91% were females. Among the 57 patients included in the study, the minimum age of the study subjects was of 26 years and the maximum age being 69 years. Mean age of the study subjects was 48.70 years with a standard deviation of 10.64 years.
Conclusion: The mean age of diagnosis of carcinoma Gall Bladder is lesser in India than that of the European countries although female preponderance is similar mostly all over the world. Further studies are required to find out such differences according to ethnicity and gender.
Keywords: Gall Bladder Carcinoma, diagnosis, earlier age, females.
References
- Consensus document for management of gallbladder cancer Prepared as an outcome of ICMR Subcommittee on Gallbladder Cancer. Available from: https://www.icmr.nic.in/sites/default/files/guidelines/GALLBLADDER%20CANCER_0.pdf.[Last accessed on 2019 July 5].
- Nandakumar A, Gupta PC, Gangadharn P, Visweswara RN, Parkin DM. Geographic pathology revisited: development of an atlas of cancer in India. Int J Cancer 2005; 116:740-754.
- Dhir V, Mohandas KM. Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol 1999; 18:24-28.
- National Cancer Registry Programme. Consolidated report of the Population Based Cancer Registries 1990-96. New Delhi: Indian Council of Medical Research 2001.
- National Cancer Registry Programme. Three year report of the Population Based Cancer Registries 2006-2008. New Delhi: Indian Council of Medical Research 2010.
- Murthy NS, Rajaram D, Gautham MS et al. Trends in incidence of gallbladder cancer – Indian scenario. In: Gastrointestinal cancer: Targets and therapy 2011;1:1-9.
- Unisa S, Jagananth P, Dhir V, Khandelwal C, Sarangi L and Roy TK. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin or North India. HPB 2011; 13:117-125.
- Eslick GD. Epidemiology of gallbladder cancer. Gastroenterol Clin North Am. 2010;39(2):307-30.11.
- Scott TE, Carroll M, Cogliano FD, Smith BF, Lamorte WW. A case-control assessment of risk factors for gallbladder carcinoma. Dig Dis Sci. 1999;44(8):1619-25.
- Ishiguro S, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S. Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study); with special focus on cholelithiasis, body mass index, and their effect modification. Cancer Causes Control. 2008;19(1): 33-41.
- Hsing AW, Gao YT, Han TQ, et al. Gallstones and the risk of biliary tract cancer: a population-based study in China. Br J Cancer 2007;97:1577-1582.
- Alvi AR, Siddiqui NA, Zafar H. Risk factors of gallbladder cancer in Karachi-a case-control study. World J Surg Oncol. 2011 Dec 9;9:164. doi: 10.1186/1477-7819-9-164.
- Dixit VK, Babu AV (2015) Carcinoma of Gallbladder. J Gastrointest Dig Sys 5: 310. doi:10.4172/2161-069X.1000310
- http://cancerindia.org.in/gall-bladder-cancer/
- Pandey M (2003) Risk factors for gallbladder cancer: a reappraisal. Eur J Cancer Prev 12: 15-24.
- Gallbladder Cancer Incidence and Mortality, United States 1999-2001. Available from: http://cebp.aacrjournals.org/content/24/9/1319.full#ref-list-1.
Corresponding Author
Dr Atrayee Chatterjee
Burdwan Medical College & Hospital, Purba Bardhaman