Abstract

Introduction: Endometrial carcinoma is the second most common malignant tumor of female genital system in India and its incidence is increasing globally. Histological variants include endometrioid carcinoma, serous carcinoma, mucinous adenocarcinoma, clear cell carcinoma, mixed adenocarcinoma and others. Histopathologic prognostic parameters include tumor type, depth of invasion, lymphovascular involvement, FIGO grade and stage.

Materials and Method: A cross sectional study was conducted in the department of Pathology, Government medical college, Thrissur, during a period of 18months. Gross examination and morphological assessment of 37 cases of carcinoma endometrium were done.  Study was approved by the institutional ethical committee.

Result: 83.8% of endometrial carcinomas were endometrioid type, 16.2% were nonendometrioid type. 77.42%, 16.13% and 6.45% of endometrioid carcinomas were grade I, grade II and grade III respectively. 64.86% of endometrial cancers were stage I tumors. Glandular pattern was the predominant pattern (54.1%). 51.4% cases showed invasion less than half of myometrium. Prominent lymphocytic infiltrate was seen in 29.73% cases. Lymphovascular emboli were seen in 10.8% cases. Mitosis was ≤5 in 86.5% cases.

Conclusion: Most cases of endometrial carcinomas were of endometrioid type, with a predominance of grade I tumors. Majority of endometrial carcinomas belonged to FIGO stage Ia.

Keywords: Endometrial carcinoma, uterine cancer, endometrioid carcinoma, serous carcinoma