Abstract
Introduction: Japanese encephalitis (JE) is a common mosquito borne viral encephalitis. Most infections of JE are asymptomatic but if clinical illness develops, it causes significant morbidity and mortality.
Aims and Objectives: To assess the serum electrolytes (Na+ and K+) in diagnosed cases of Japanese Encephalitis.
Materials and Methods: The study was carried out in Gauhati Medical College and Hospital, Guwahati, India between January, 2014 and July, 2015. Serum sodium and potassium levels in 100 diagnosed patients of Japanese Encephalitis was assayed in Vitros 5600 Analyser of Ortho Clinical Laboratories by the slide method that uses direct potentiometry for analysis of the ions. Equal number of age and sex matched healthy individuals were taken as control group.
Results and Observations: The present study shows that there is highly significant decrease in the serum sodium levels in the study group as compared to the control group (**p<0.001).On the other hand, there is no significant difference in potassium levels between the study group and the control group (p>0.05).
Discussion: There is highly significant decrease in the values of serum sodium levels in cases of Japanese Encephalitis, which may occur as a consequence of SIADH.
The findings of the present study thus have an impact in the treatment protocol, as hyponatremia impairs cerebrovascular reactivity. Maintenance of serum sodium level at the ideal level will lead to a significant decrease in both mortality and morbidity.
Keywords: Hyponatremia, Japanese Encephalitis, Serum potassium, Serum sodium.
References
- Rao PN. Japanese encephalitis. Indian Pediatrics. 2001; 38: 1252-1264.
- Japanese Encephalitis: Bangladesh Perspective: A Review Sultana M Hussain , A R M Saifuddin Ekram , M J Hossain , E Gurley , S Lubey . TAJ June 2004; Volume 17 Number 1
- Tsai TF. New initiatives for the control of Japanese encephalitis by vaccination. Minutes of a WHO/CVI meeting, Bangkok, Thailand, 13-15 October 1998, Vaccine 2000: 18: 1-25.
- Rodhain F. Recent data on the epidemiology of Japanese encephalitis. Bull Acad Natl Med 1996; 180: 1325-1340.
- Rojanosuphot S, Tsai TF. Regional Workshop on Control Strategies for Japanese Encephalitis. Southeast Asian J Trop Med Pub Health 1995; 26: (S3): 1-59.
- Reuben R, Gajanana A. Japanese encephalitis in India. Indian J Pediatr 1997;64:243-51
- Patgiri SJ, Borthakur AK, Borkakoty B, Saikia L, Dutta R, Phukan SK. An appraisal of clinicopathological parameters in Japanese encephalitis and changing epidemiological trends in upper Assam, India. Indian J Pathol Microbiol 2014;57:400-6.
- Directorate of National Vector Borne Disease Control Programme, Delhi. Details of AES/JE Cases and Deaths from 2008-2013 (till 31 stJan). Available from: http://www.nvbdcp.gov.in/Doc/je-aes-cd-tillJan13.pdf (Last accessed on: 27.02.2013).
- Pareek S, Roy S, Kumari B, Jain P, Banerjee A, Vrati S. MiR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses. Journal of neuroinflammation. 2014 May 29;11(1):97.
- Lindenbach BD, Thiel Heinz-Jurgen Rice CM. 2007. Flaviviridae: the viruses and their replication, p 1101–1152. In Knipe DM, Howley PM (ed), Fields virology, 5th ed, vol 1. Lippincott-Raven Publishers, Philadelphia, PA
- Unni SK, Růžek D, Chhatbar C, Mishra R, Johri MK, Singh SK. Japanese encephalitis virus: from genome to infectome. Microbes and Infection. 2011 Apr 30;13(4):312-21.
- Abe, T., Kojima, K., Shoji, H., Tanaka, N., Fujimoto, K., Uchida, M., Nishimura, H., Hayabuchi, N. and Norbash, A. M. (1998), Invited. Japanese encephalitis. J. Magn. Reson. Imaging, 8: 755–761. doi: 10.1002/jmri.1880080402
- Solomon T, Dung NM, Kneen R, Gainsborough M, Vaughn DW, et al. (2000) Japanese encephalitis. J Neurol Neurosurg Psychiatry 68: 405–415.
- Solomon T, Kneen R, Dung NM, Khanh VC, Thuy TT, et al. (1998) Poliomyelitis-like illness due to Japanese encephalitis virus. Lancet 351: 1094–1097.
- Solomon T (2004) Flavivirus encephalitis. N Engl J Med 351: 370–378
- Burke DS, Lorsomrudee W, Leake CJ, Hoke CH, Nisalak A, et al. (1985) Fatal outcome in Japanese encephalitis. Am J Trop Med Hyg 34: 1203–1210.
- Vaughn DW, Hoke CH Jr (1992) The epidemiology of Japanese encephalitis: prospects for prevention. Epidemiol Rev 14: 197–221.
- Kaur R, Vrati S (2003) Development of a recombinant vaccine against Japanese encephalitis. J Neurovirol 9: 421–431.
- Lee JW. Fluid and electrolyte disturbances in critically ill patients. Electrolyte Blood Press. 2010;8:72–81.
- Funk GC, Lindner G, Druml W, et al. Incidence and prognosis of dysnatremias present on ICU admission. Intensive Care Med. 2010;36:304–311.
- Umenai T, Krzysko R, Bektimirov A., Assaad FA. Japanese encephalitis: current world status.WHO Bulletin OMS1985; 63: 625–631
- Reuben, R. & Gajanana, A. Indian J Pediatr (1997) 64: 243. https://doi.org/10.1007/BF02752458
Corresponding Author
Dr Mousumi Borgohain Borah
Assistant Professor, Department of Biochemistry,
Gauhati Medical College & Hospital, Guwahati
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.75
