Abstract
Aim: To determine the prevalence of metaplasia and dysplasia among south Indian patients undergoing cholecystectomy.
Materials and Methods: Patients undergoing laparoscopic/ open cholecystectomy from January 2015 to December 2016 were included. Retrospective data on age, sex, residence and presence of common bile duct stones was collected. Peri operative information included colour of gallstones and histopathology of the gallbladder.
Results: 235 gallbladder specimens (115 males) with median age of 49.3 years (17-83 years) were studied. Chronic cholecystitis was the commonest pathological finding followed by acute on chronic cholecystitis, acute cholecystitis and acute necrotising cholecystitis respectively. Six specimens (2.5%) showed an antral metaplasia and one each (0.4%) had focal micropapillary changes and low grade dysplasia.
Conclusion: Gallstone related cholecystitis in south India is often chronic and affects men and women equally. Chronic cholecystitis though the commonest pathological type was not associated with metaplasia or gallbladder cancer.
Keywords: gall bladder, premaliganat, India, mucosa.
References
- Randi G, Franceschi S, Vecchi CL. Gallbladder cancer worldwide: geographical distribution and risk factors.Int J Cancer. 2006;118:1591–1602. doi: 10.1002/ijc.21683.
- Diehl AK. Epidemiology of gall bladder cancer: A synthesis of recent data.J Natl Cancer Inst. 1980;65:1209–1214
- Tominaga S, Kuroishi T. Biliary tract cancer.Cancer Surv. 1994;19–20:125–137.
- Fraumeni JF, Jr, Devesa SS, McLaughlin JK, Standford JL. Biliary tract cancer. In: Schottenfeld D, Fraumeni JF, editors.Cancer epidemiology and prevention. New York: Oxford University Press; 1996. pp. 795–805.
- Zatonski WA, Smans M, Tyczynski J, Boyle P (1996) Atlas of cancer mortality in Central Europe. Lyon: IARC 56–9
- Kapoor VK, McMichael AJ. Gallbladder cancer: An ‘Indian’ disease.The Nat Med Jour India. 2003;16:209–213.
- Zatonski WA, Lowenfelds AB, Boyle P, et al. Epidemiologic aspects of gall bladder cancer: A case–control studyof the SEARCH programme of the International Agency for Research on Cancer.J Natl Cancer Inst. 1997;89:1132–1138. doi: 10.1093/jnci/89.15.1132.
- Shanta V, Vendhan Gajalakshmi V, Swaminathan R, Rama R. Population based cancer registry, Chennai. Cancer Institute (WIA), Adyar, Chennai. Indivi-dual Registry Data: 1990–1996; 173–94
- Gokulakrishnan S, Murugesan R, Mathew S, Prasanthi R, Ashok AC, Ramesh H, Sivakumar G, Surendran R, Jayanthi V. Predicting the composition of gallstones by infrared spectroscopy. Tropical Gastroenterology 2001; 22:87-89
- Mathur SK, Duhan A, Singh S et al. Correlation of gall stone characteristics with mucosal changes in gallbladder. Tro-pical Gastroenterology 2012;33(1):39–44
- Mondal B, Maulik D, Biswas BK, Sarkar GN, Ghosh D. Histopathological spectrum of gallstone disease from cholecystectomy specimen in rural areas of West Bengal, India- an approach of association between gallstone disease and gallbladder carcinoma. Int J Community Med Public Health 2016;3: 3229-35
- Sangwan MK, Sangwan V, Garg MK, Singla D, Malik P, Duhan A. Incidental carcinoma of gallbladder in north India: is routine histopathology of all cholecystectomy specimens justified? Int Surg J 2015;2: 465-7
- Devi S, Kalita D. J. Metaplasia-dysplasia-carcinoma sequence in cases of cholelithiasis: a histopathological study. Int J Med Res Rev 2016;4 (7):1092-1096.doi: 10.17511/ijmrr.2016.i07.03
- Dattal DS, Kaushik R, Gulati A, Sharma VK. Morphological spectrum of gall bladder lesions and their correlation with cholelithiasis. Int J Res Med Sci 2017;5:840-6
- Jayanthi V, Sarikha S, Varghese J et al. Composition of Gallbladder Bile in Healthy Individuals and Patients With Gallstone Disease From North and South India. Indian J Gastroenterol 2016; 35, 347-353
- Jayanthi V, Palanivelu C, Prasanthi R, Mathew S, Srinivasan V. Composition of gallstones in Coimbatore District of Tamil Nadu state. Indian J Gastroenterol. 1998;17:134–5.
Corresponding Author
Mayank Jain
Gleneagles Global Health City Chennai-100
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