Abstract
Present study relates to the results of haematological investigations of 13 patients with vivax malaria. One of the 13 patients had moderate anaemia. Eight other patients had mild anaemia. Four other patients had normal haemoglobin (Hb) concentration. Leucopenia was detected in two patients. Three patients had lymphopenia. Two other patients developed mild eosinophilia. Thrombocytopenia was detected in 12 of 13 patients (92%). Three patients had severe thrombocytopenia (platelets <0.5 lac/mm3). Six patients had moderate thrombocytopenia (platelets 0.5 lac to <1 lac/mm3). Three other patients had mild thrombocytopenia (platelets 1 lac to <1.5 lac/mm3). Thrombocytopenia might have developed subsequent to bone marrow suppression of megakaryocytes or due to platelet sequestration by splenic macrophages. In patients, results of product moment correlation (r) revealed direct correlation between Hct and neutrophil count (r = 0.932) and between MCHC Vs neutrophil count (r = 0.467). In addition, inverse relation was detected between MCV vs WBC (r = - 0.523) and between MCV vs neutrophil count (r = - 0.382). These observations suggested that Hct, MCHC and MCV all might affect neutrophil count in malaria.
Keywords: Plasmodium - induced reduction of platelets.
References
- Nirmala, Kumar Archana, Kapoor AK, Lal B, Dutta GP, Swaroop A. Plasmodium falciparum: Drug-resistant malaria complicating leukemias and lymphomas in children. Experimental parasitology 1999; 93: 33-37.
- Kapoor AK, Nirmala, Lal B, Dutta GP. Detection of raised serum ferritin levels in patients with Falciparum malaria. J Nepal Gunj Medical College 2001; 1: 21-23.
- Muley Arti, Lakhani J, Bhirud S, Patel A. Thrombocytopenia in Plasmodium vivax malaria : How significant ? J Tropical Med 2014; 2014, 1-4.
- Kochar DK, Tanwar GS, Khatri et al. Clinical features in children hospitalized with malaria : a study from Bikaner, Northwest India. Amer J Trop Medicine and Hygiene 2010; 83: 981-989.
- Kochar DK, Das A, Kochar A, Middha S, Acharya J et al. Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria : a study from Bikaner (Northwestern India). Platelets 2010; 21: 623-627.
- Coelha HCC, Lopes SCP, Pimentel JPD, Nogueira PA, Costa FTM, Siqueira AM, Melo GC, Monteiro WM, Malheiro A, Lacerda VG. Thrombocytopenia in Plas-modium vivax malaria is related to platelet phagocytosis. PLOS ONE 2013; 8(5): e 63410 doi:101371/Journal. Pone. 0063410.
- Kishiyama JL, Tevrizian AT, Avila PC. Drug Allergy. Chapter 30, In Parslow TG, Stites DP, Terr AI, Imboden JB (editors). Medical Immunology 10th New York : Lange medical books / McGraw-Hill publishing division : 2001, 394-400.
- Bithel TC, Miscellaneous forms of thrombocytopenia, Chapter52. In Lee GR, Bithel TC, Foerster J, Athens JW, Lukens JN (editors), Wintrobe’s clinical Hematology, Lea & Febiger, Philadelphia (publisher) : 1993, 1363-73.
- Panichakul T, Payuhakrit W, Panburama P, Wongborisuth C, Hongeng S, Undoms-angpetch. Suppression of erythroid development in vitro by Plasmodium vivax. Malaria Journal 2012; 11:175, 3-22.
- Miller LH, Good MF, Milon G. Malaria pathogenesis. Science1994;264:1878-1883
- Castro-Gomes T, Mourao LC, Melo GC, Monteiro WM, Lacerda MVG, Braga FM. Potential immune mechanisms associated with anaemia in Plasmodium vivax malaria : a puzzling Question. Infection and immunity 2014; 82: 3990-4000.
- Abro AH, Ustadi AM, Younis NJ, Abdou AS, Hamed DA, Saleh AA. Malaria and hematological changes Pakistan J of Medical Sciences 2008; 24, 287-291.
- Anderson RM, May RM. Vaccination and herd immunity. Nature 1885;318:323-329.
- Plorde JJ, White NJ. Malaria, Chapter 154, In Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Fauci AS (editors). Harrison’s principles of internal medicine 11th edition, New York : 1987, p 778-84.
- Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itaguki S, Horli T, Lin J, Khan SM, Kuroda E, Akira S, Ishii KJ, Coban C. Plasmodium products persist in the bone marrow and promote chronic bone loss. Science Immunology 2017, 2:eaam 8093, p1-11.
Corresponding Author
Dr Ashok Kumar Kapoor
RML Mehrotra Pathology Pvt Ltd, Nirala Nagar, Lucknow-226020, Uttar Pradesh, INDIA
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i8.81
