Abstract
Introduction: Many women increasingly delay pregnancy and childbirth into their later decades of life because of different reasons, such as delay in marriage, educational and professional reasons. Advanced maternal age has been regarded as adverse foetal and neonatal outcome in pregnancy.
Objective: This study is aimed at comparing the foetal and neonatal outcomes of pregnancy in women aged 35 years and above.
Methods: Prospective comparative observational study was done over a period of 2 year at the M.M. Medical College & Research Centre, Mullana, Ambala (Haryana) India.
Forty pregnant women of age 35 years and above at any gestational age were taken into the study population irrespective of the parity. Forty control population was pregnant women of age 20-34 years of any parity.
Results: The incidence of low APGAR score at minutes, foetal complications, birth asphyxia, admission to NICU was found to be higher in the study group.. This study did not find any significant difference in mean gestation age, mean birth weight in elderly women. No foetal malformations were seen in both the groups.
Conclusion: Pregnancy in older women seem to have more adverse foetal and neonatal outcome .Women should be informed that the risk of adverse foetal and neonatal outcome increases with age.
Keywords: maternal age, foetal malformation, foetal and neonatal outcome.
References
- Balasch J and Gratacos E , “Delayed childbearing: effects on fertility and the outcome of pregnancy,” Fetal Diagnosis and Therapy, 2011; vol. 29, pp. 263–273.
- Bayrampour H, Heaman M, DuncanKA, and Tough S,“Advanced maternal age and risk perception: a qualitative study,” BMC Pregnancy Childbirth, 2012; vol. 12, article 100.
- Bianco A, Stone J, Lynch L, Lapinski R, Berkowitz G,Berkowitz R. Pregnancy outcome at age 40 and Obstet Gynecol 1996;87:917–22.
- Berkowitz GS, Skovron ML, Lapinski RH, Berkowitz RL.Delayed childbearing and the outcome of pregnancy.N Engl J Med 1990;322:659–64.
- Cnattingius S, Forman M, Berende SH, Isotalo. Delayed childbearing and risk of adverse perinatal JAMA.1992; 268:886 –90.
- Prysak M, Lorenz R, Kisly A. Pregnancy outcome in nulliparous women 35 years and older. Obstet Gynecol.1995;85:65–70.
- Seoud M, Nassar AH, Usta IM, Melhem Z, Kazma A,Khalil AM. Impact of advanced maternal age on Pregnancy out come. Am J Perinatol 2002;19:1–7.
- Vercellini P, Zuliani G, Rognoni MT, Trespidi L, Oldani S, Cardinale A. Pregnancy at forty and over: a case control study. Eur J Obstet Gynecol Reprod Biol 1993;48:191–5.
- Ales K, Druzin M, Santibi D. Impact of advanced maternal age on the outcome of pregnancy. Surg Gynecol Obstet.1990; 171:209 –16.
- Kirz DS, Dorchester W, Freeman RK. Advanced maternal age: the mature gravida. Am J Obstet Gynecol 1985;152:7–12.
- Chan BCP, Lao TT. Influence of parity on the obstetric performance of mothers aged 40 years and Hum Reprod. 1999;14:823-37.
- Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, Saade GR, et al. Impact of maternal age on obstetric outcome. Obstet Gynecol 2005; May;105(5 Pt 1):983-90.
- Joseph KS, Alexander C. Allen, Linda Dodds, Linda Ann Turner, Heather Scott, Robert Liston. The perinatal effects of delayed childbearing. Obstet Gynecol. 2005;105:1410-8.
- Sahu T. Meenakshi, Agarwal Anjoo, Das Vinita. Advanced maternal age and obstetric outcome. J Obstet Gynecol India. 2007;57:320-3.
- Bobrowski R, Bottoms S. Underappreciated risks of the elderly multipara. Am J Obstet Gynecol.1995 ;172:1764–70.
- Ziadeh S and Yahaya A, “Pregnancy outcome at age 40 and older,” Archives of Gynecology and Obstetrics 2001; vol. 265, no. 1, pp.30–33.
Corresponding Author
Kiran Kumar Singal
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