Abstract
Background: The objective of this study was to compare the effects of intravenous dexmedetomidine and saline placebo on intra operative haemodynamics in hypertensive patients.
Methods: In a double blinded trial, forty hypertensive patients were randomly allocated to receive either dexmedetomidine 0.5 μg /kg/h (Group D) (n = 20) or saline placebo (Group N) (n = 20) intra-venously, started immediately after intubation. Heart rate (HR) and mean arterial pressures (MAPs) were recorded throughout.
Results: Dexmedetomidine caused significant fall in MAP, 15 min after starting infusion (P<0.001). Also, patients in group D had fall in heart rate and MAP (P= 0.244) while in Group N showed mild increase in heart rate and a highly significant fluctuation in MAP (P<0.001).
Conclusion: These findings suggest that an infusion of dexmedetomidine in hypertensive patients attenuates circulatory reflexes during surgery and at extubation, thus provided stable haemodynamics both intra operatively and at extubation.
Keywords: Dexmedetomidine; hypertension; responses; tracheal; extubation.
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Corresponding Author
Sheeba Franklin
Njondimackal, Thellakom. P.O, Kottayam
Telephone no; 0481-2791655, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.232
