Abstract
Background: Cancer, a term that elicits a shock in the nerve endings of every individual touches every country in the world.
Material and Method: It was a prospective observational study. The study was carried out between November 2015 to April 2016 conducted in medical Oncology & Radiation Oncology Department in P.B.M. hospital and associated group of hospital, Bikaner.
Result: female 43(252) were more affected by ADR as compared to male patients 34 (164). anaemia (14.42%) was the most common ADR followed by Vomiting (10.34%) and Nausea (9.13%).
Conclusion: Chemotherapeutic drugs have a narrow therapeutic index and the dosage needed to achieve a therapeutic response usually proves toxic to the body’s rapidly proliferating cells.
Keywords: ADRs, Cancer, Chemotherapy.
References
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. Cancer J Clin 2011 Mar-Apr; 61(2):69-90.
- Javed, S., Ali, M., Sadia, S., Aslam, M.A., Masood, A.I., Shaikh, R.S. and Sayyed, A.H. Combined Effect of Menopause Age and Genotype on Occurrence of Breast Cancer Risk in Pakistani Population. Maturitas 2011;69: 377-382.
- Mark Kirstein. Neoplastic Disorders and their treatment: General Principles, Section 19, Chapter 88-2. In: Applied Therap-eutics; The Clinical Use of Drugs, 9th Lippincott Williams and Wilkins. 2009
- World Health Organization (WHO). World Cancer Report 2014: Cancer Fact sheet N°297. 2014.
- Parkin DM. The global health burden of infection-associated cancers in the year 2002. International Journal of Cancer, 2006; 118:3030–304
- Dikshit R, Gupta PC, Ramasundarahettige C, et al. Cancer mortality in India: a nationally representative survey .Lancet 2012;379(9828):1807-16
- National Cancer Registry Programme. Consolidated report of the population based cancer registries1990-1996. New Delhi: Indian Council of Medical Research; 2001.
- Sarnath D, Khanna A. Current Status of Cancer Burden:Global and Indian Scenario.Biomedical Res J.2014;1(1):1-
- Government of india,Ministry of health and family welfare;Department of health and family welfare;Lok sabha Starred question no. 98 http://admin.indiaenvironmentportal.org.in/files/file/cancer%20cases.pdf
- http://www.ey.com/Publication/vwLUAssets/EY-expanding-cancer-care-in-india Call-for-action Date of access: 5 july2016
- Patrick J. Medina. Cancer treatment and chemotherapy. In: Joseph T.Dipiro, Gary C.Yee editors. Pharmacotherapy – A Pathophysiologic Approach, 7th edition. United States: McGraw – Hill 2008:p. 2085- 2116.
- Joel G. Hardman. Chemotherapy of neoplastic diseases. In: Goodman & Gilman’s. The Pharmacologic Basis of Therapeutics. 9th edition. McGraw-Hill, New York. p. 1381-1388
- Tripathi KD. Anticancer drugs. Essentials of medical pharmacology. 7th ed. New Delhi: Jaypee 2013: 857-877
- Stohr W, Paulides M, Bielack S, Jurgens H, Koscielniak E, Rossi R, et al. Nephrotoxicity of cisplatin and Carboplatin in sarcoma patients: a report from the late effects surveillance system. Pediatric Blood Cancer 2007; 48(2):140-7.
- Goodman Gilman's The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw-Hill 2011 :p.1667
- Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients. J Am Med Assoc 1997; 277:301–6.
- Lee A, Thomas SHL . Adverse drug reactions. In: Clinical Pharmacy and Therapeutics Roger. (3rd ed), Churchill Livingstone, Spainp 2003:33-34.
- Passarelli MCG, Filho WJ. Adverse drug reaction in elderly patients: how to predict them? Einstein 2007; 5(3):246-251
- Kirthi C, Afsal A, Reddy M, Ali AS, Aparna Y, Sharma S. A study on the adverse drug effects of anti-cancer drugs in an oncology center of a tertiary care hospital. Int J Pharm Sci 2014;6:580-3.
- Cancer Therapy .Cancer Scenario in India with Future Perspectives 2011;8:56-70.
- Bates, D.W. and Leape, L. Adverse Drug Reaction. In: Morreli's Clinical Pharmacology. Boston: McGraw-Hill 2012. pp. 1223-1257.
- Sunil Bellare et al.Adverse Drug Reaction due to Cancer Chemotherapy Journal of Young Pharmacists 2016;8(3):71-74.
- Sasmi MB. Adverse drug reaction profile of cisplatin-based chemotherapy regimen in a tertiary care hospital in India. Int J Basic Clin Pharmacol 2015;4:1214-9.
- Kaur K, et al. Spontaneous adverse drug reaction monitoring in oncology: Our experience. Indian J Cancer 2015;52:467-70
- Goyal Y N et al. Pattern of adverse drug reaction due to cancer chemotherapy in tertiary care teaching hospital in Gujarat. IJSR- international journal of scientific research 2014;3 (1):2277 – 8179.
Corresponding Author
Amritpal Singh
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.