Title: Arsenic- Exposure, Mechanism of Action and Toxicity Analysis: A Prenatal View
Author: Shagun Shukla
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.133
Abstract
Arsenic continues to poison the drinking water of thousands across the globe. Numerous studies have evaluated the carcinogenic potential of lifetime exposure and also the ill effects of prenatal exposure. Population Studies have revealed the strong correlation between the development of skin, bladder, kidney and lung cancer and arsenic exposure in endemic areas. Although the adult exposure outcomes continue to be evaluated, the prenatal exposure aspect is neglected in most studies. Our study aims to explore the co carcinogenic effect of prenatal arsenic exposure. Most experiments conducted so far in this topic utilizes models of adult exposure and very few studies have reported association of prenatal exposure to any type of carcinogenesis. This study will address the underlying mechanisms behind this association. The knowledge derived from the study can be used to develop or design early life detection markers for in utero arsenic exposure and the anomalies that may ensue.
Keywords-Arsenic, in utero, biomethylation of arsenic, tumor, carcinogenesis, prenatal.
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Shagun Shukla
Jaypee Institute of Information Technology, Noida, India
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