Mean Platelet Volume as an Independent Risk Factor for Acute Myocardial Infarction and Its Short Term Prognostic Significance

Title: Mean Platelet Volume as an Independent Risk Factor for Acute Myocardial Infarction and Its Short Term Prognostic Significance

Authors: Dr Ajitha Kesi Chellappan, Dr Sajan Christopher

DOI: https://dx.doi.org/10.18535/jmscr/v5i7.86

Abstract

Background of study: The biological events that occur in the Coronary system immediately preceding acute coronary syndromes are still unclear. However platelets are definitely involved, and changes in platelet structure may be a casual factor in producing a thrombus in the coronary artery. Platelet activation, by favouring thrombus formation and coronary artery occlusion is thought to play a key pathogenic role in acute myocardial infarction¹

It has been shown that platelet size, measured as mean platelet volume (MPV) correlates with their reactivity³. Circulating platelets are heterogeneous in size density and reactivity¹⁰. Platelet age & size are independent determinants of platelet function⁵. Mean platelet volume is positively associated with indicators of platelet activity including expression of glycoprotein 1b and glycoprotein IIb/IIIa receptor on many studies. Elevated MPV has been recognised as independent risk factor for myocardial infarction^6,

In acute stages of platelet activation, an increase in platelet volume might be a result of a change in fragmentation pattern of megakaryocyte.

The goal of the study was to assess MPV in patients with acute myocardial infarction (AMI) admitted within 3 hours of chest pain, and its short term prognostic significance.

References

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14. Jagroop, I.A. & Mikhailidis, D.P. (2000) Angiotensin II can induce and potentiate shape change in human platelets: effect of losartan. Journal of Human Hypertension, 14, 581 – 585. |

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16. Glud T,Schmidt EB,Kristensen SD Arnfred T. (1986)Platelet number and mean platelet during myocardial infarction in relation to infarct size.Acta Med Scand,220(5):401-5.

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