Title: Assessment of enzymatic markers in patients of chronic alcoholic liver disease attending OPD of a tertiary health care level Institute of North India
Authors: Indra Prasad Adhikari, Dr Ipsita Choudhury, Dr Pallavi Anand, Dr Sonam Bhatia, Dr Rajju Tiwari
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.67
Abstract
Background: Alcoholic Liver disease (ALD),is a term that encompasses the hepatic manifestations of alcohol over consumption that includes- fatty liver, alcoholic hepatitis and chronic hepatitis with cirrhosis. Although Only 15% alcoholics develop liver disease even than alcohol is strong morbidity agent among alcoholics. As a markers of liver damage in case of alcoholic Liver disease, enzymes which are mainly important are- ALP- Alkaline Phosphatase, GLD- Glutamate Dehydragenese and 5 NTP-5’ Nucleotidase etc.
Objective: To evaluate the status of enzymatic markers in alcoholic liver disease & to compare the enzymatic markers of alcoholic liver disease among the cases and control. Materials and Methods: Total 100 participants were enrolled as sample size among of them 50 patients attending OPD of Rama Medical college of Rama University, Kanpur were enrolled as cases and remaining 50 healthy individuals of same profiles were enrolled as controls in this study. 5 ml fasting Venous samples was taken for serum measurement of enzymatic markers of ALD patients and normal healthy individuals and samples were analysed in auto analysers.
Results: In the present study the mean age of cases was 48.06±10.07 yrs and in control group it was found 46.36±9.61yrs. (p = 0.390) and the mean weight of cases was 64.52± 6.08 kgs and in control group it was found 64.30± 6.03 kgs.( p=0.856) and the enzymatic markers i. e. SGOT,SGPT ALP and GGT were found to be significantly higher in cases than control, (p<0.05)
Conclusion: In the present study the status of enzymatic markers (AST,ALP,ALT,GGT) were evaluated in alcoholics liver disease. A significant association was obtained in the enzymatic markers between the alcoholics and non-alcoholics. It can be concluded that the level of enzymatic markers like AST,ALP,ALT and GGT are raised in alcoholics as compared to non-alcoholics.
Keywords: Alcoholic Liver Disease(ALD), AST,ALT,GGT.
