Abstract
Anaemia observed in patients with infectious, inflammatory or neoplastic diseases that persist for more than 1 or 2 months is called anaemia of chronic disease. The purpose of this study was to study the various morphological types of anaemia in Anaemia of chronic disease and to correlate bone marrow iron stores and serum ferritin in these patients. This study was conducted in Post Graduate Department of Pathology ASCOMS, Sidhra, Jammu for a period of one year. It was concluded from the study that normocytic normochromic anaemia was the most common type of anaemia and there exists a positive correlation between serum ferritin and bone marrow iron stores in patients of Anaemia of chronic Disease.
Keywords: RBC Indices, bone marrow iron stores, anaemia of chronic disease, rheumatoid arthritis, tuberculosis, malignancy, serum ferritin.
References
1. EJ Fitzsimons, JH Brock. The anaemia of chronic disease. British Medical Journal 2001;322:811.
2. Spivak JL. Iron and the anaemia of chronic disease. Oncology (Williston Park) 2002 Sep; 16: 25-33.
3. Witte DL, Dick FR, Goeken J, Johnson G, Pennell B. C reactive protein aids interpretation of serum ferritin. Journal of Clinical Chemistry 1985; 31:1011.
4. Bain BJ, Lewis SM. Preparation and staining methods for blood and bone marrow films. In Lewis SM, Bain BJ, Bates I (eds): Dacie and Lewis Practical Haematology; 10th edition; Churchill Livingstone, Philadelphia 2006: 60-64.
5. Daice and Lewis. Practical Haematology, 10th edition. Churchill Livingstone Publication, 2001
6. MD Joseph M. Cash, MD David A. Sears. The anemia of chronic disease: spectrum of associated diseases in a series of unselected hospitalised patients. The American Journal of Medicine 1989 Dec.87(6)0; 638-44.
7. Frank H. Wians, Jr., Jill E. Urban, Joseph H. Keffer, Steven H. Kroft. Discriminating between iron deficiency anaemia and anaemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration. American Journal of Clinical Pathology 2001; 115:112-118.
8. Baynes RD, Flax H, Bothwell TH, Bezwoda WR, Mac Phail AP, Atkinson P et al. Haematology and iron related measurements in active pulmonary tuberculosis. Scandinavian Journal of Haematology 1986 Mar; 36(3): 280-7.
9. Gastroenterology 1978; 13(6): 649-56. Bartels U, Pedersen NS, Jarnum S. Iron absorption and serum ferritin in chronic inflammatory bowel disease. Scandinavian Journal of
10. Porter DR, Sturrock RD, Capell HA. The use of serum ferritin estimation in the investigation of anaemia in patients with rheumatoid arthritis. Clinical and Experimental Rheumatology 1994 Mar-Apr;12(2):179-82.
11. Shroff K, Gaiha M, Singh T, et al. Iron status in patients of Rheumatoid arthritis with special reference to serum ferritin levels. J Assoc Physicians India 1991 Sep; 39(9): 675-7.
12. Baynes RD, Flax H, Bothwell TH, Bezwoda WR, Mac Phail AP, Atkinson P et al. Haematology and iron related measurements in active pulmonary tuberculosis. Scandinavian Journal of Haematology 1986 Mar; 36(3): 280-7.
13. Jakobsen E, Engest A, Sandstad B, et al. Serum ferritin and bone marrow haemos-iderin in patients with malignancies and in healthy controls. Scand J Haematol 1982 Mar; 28(3): 264-71.