Abstract
Background: Breast cancer is the leading cancer affecting females of urban India. In recent times the multidisciplinary approach to this cancer has given us new insights about its biology. New modalities of treatment and early diagnosis due to increased awareness have significantly reduced cancer related deaths. This study aims at portraying the morphological diversity of breast cancer and comparing with recent WHO (2012) classification. The multitude of histopathological variations of breast cancer intrigues us histopathologists not only from academic point of view but also helps us to guide clinicians regarding treatment and prognoses.
Material and Method: A cross sectional observational study conducted in the Department of Pathology from May 2015 to April 2017.
Result: Total 168 cases of breast carcinoma were diagnosed during this time period out of which maximum cases were clustered in the 5th decade of life. Most cases were stage T2 and showed lymphovascular invasion. The special histopathological subtypes encountered were Pleomorphic IDC, Lobular Carcinoma, Cribriform Carcinoma, Medullary Carcinoma, Mucinous Carcinoma, Invasive Papillary Carcinoma, Micropapillary Carcinoma, Apocrine Carcinoma, Secretory Carcinoma, Stromal Sarcoma, Malignant Phyllodes and Primary Lymphoma of breast.
Keywords- carcinoma breast, WHO classification, rare histological subtype.
References
1. BREASTCANCER.org. US breast cancer statistics.
2. http//www.midday.com/articles/over 17 lakh new cancer cases in india by 2020. Icmr/17248152-19/5/16
3. Who classification of Tumors of the Breast. Edited by Sunil R Lakhani, Ian O Ellis, Stuart J Schniff, Marc J van de Viver. 4th edition. Lyon IACR 2012
4. Catalina Acevedo et al.Rare breast tumors: Review of the literature. Rep Pract Oncol Radiother. 2014 Jul; 19(4): 267–274.
5. Albrektsen G et al.Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway.BMC Cancer201010:226.DOI: 10.1186/1471-2407-10-226.
6. Agarwal G, Ramakant P et al. Breast cancer care in India: the current Scenario and the challenges for the future. Breast care(Basel). 2008 Mar:3(1): 21-27.
7. G. Viale et al. The current state of breast cancer classification. Ann Oncol (2012) 23 (suppl 10):x207-x210.doi: 10.1093/annonc/mds326
8. Cong Y et al. Invasive cribriform carcinoma of breast: A report of nine cases and review of literature. Oncol Lett. 2015 April; 9(4):1753-1758.
9. Erum A et al. Medullary carcinoma of breast with atypical features- A case study. Jpms.2012 March;vol-2, issue 1.
10. Dumitru A,Procop A et al. Mucinous Breast Cancer: a Review Study of 5 Year Experience from a Hospital-Based Series of Cases. Maedica (Buchar). 2015 Mar; 10(1): 14–18.
11. Saremian J, rosa M et al. Solid papillary carcinoma of breast – A pathologically and clinically distinct breast tumor. Arch pathol lab med, 2012 October; Vol 136:pg 1308-1311.
12. Chen AC et al. Prognostic markers for invasive micropapillary carcinoma of the breast- A population based analysis. Clin Breast Cancer. 2013 Apr;13(2): 133-9
13. Wader J et al. Apocrine carcinoma of breast: A case report with Review of literature. Case reports in pathology.2013; volume 2013, Article Id 170918
14. Dali Li, Xiuying et al. Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. Modern Pathology (2012) 25, 567–575; doi:10.1038/modpathol.2011.190; published online 9 December 2011
15. Grabowski J et al. malignant Phyllodes Tumor: a review of 752 cases. Am Surg. 2007 Oct; 73(10): 967-9
16. C Adem , C Reynolds et al. Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. British Journal of Cancer (2004) 91, 237–241. doi:10.1038/sj.bjc.6601920 .Published online 8 June 2004.
17. De Padua M et al. Primary lymphoma of breast- A clinicopathological study. Indian J Pathol Microbiol. 2007 Oct;50(4):722-5.
18. Reimer T. Management of rare histolo-gical types of breast tumours. Breast Care (Basel) 2008;3:190–196.
19. Carbone S., Lobo Alvarez R., Lamacchia A. Primary squamous cell carcinoma of the breast: a rare case report. Rep Pract Oncol Radiother. 2012;17:363–366.
20. Soares A., Gonçalves J., Azevedo I. Lobular ectopic breast carcinoma: a case-report. Rep Pract Oncol Radiother. 2013;18:189–191.
Corresponding Author
Dr Moulima Banerjee
Department Of Pathology, R.G.Kar Medical College and Hospital
1, Khudiram Bose Road, Kolkata-700004, West Bengal. India
Phone Number- 9635972747, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.