Title: Study of Correlation of Retinal Layer Thickness with Duration and Severity of Parkinson’s Disease
Authors: Dr Kunal B Jadhav, Dr R Balakrishnan, Madhavi Karri
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.220
Abstract
PD is primarily a motor disorder associated with loss of dopaminergic neurons. Dopamine (DA) is also a major neurotransmitter in the retina. There is concurrent retinal DA neurons loss in in the inner nuclear &inner plexiform layers in PD. OCT is analogous to ultrasound & its provides detailed cross sectional images of retina.
Aim: To do the macular scans, parapapillary RNFL in vivo & to evaluate whether retinal structural changes are seen in PD &its relation to the clinical severity of the PD.
Materials & Method: Our prospective study was conducted in PSG Hospital IMS&R. Spectral OCT Was used to examined the RNFL thickness in all quadrants & Macular volume in PD patients without visual impairment (n=25) & compared them with healthy age, sex matched control (n=25). PD severity will be assessed using the Hoehn &Yahr scale.
Results: Compared to healthy control the thickness in the inferior quadrant of PD patients (149±6 microns) showed statistically significant thinning of the inferotemporal area (145±25 vs.190±20 microns).Significant differences were observed between controls and patients in relation to mean macular thickness PD duration & severity were inversely correlated
Conclusion: RNFL thickness & macular thickness could be a surrogate biomarker for PD diagnosis in early stage aid in monitoring treatment effectiveness & monitoring disease progression in PD.
Keywords- Parkinson’s disease Retina; Retinal nerve fiber layer; Optical coherence tomography.
