Title: Neonatal Septicemia: Bacterial Isolates & Their Antibiotics Susceptibility Patterns: A Hospital Based Study
Authors: Dr Basavaraj M S, Mr Rashmiranjan Rout, Gagan Priya Pandey
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.181
Abstract
In neonates, sepsis incidence is increasing in the recent years. Neonatal septicemia is an important cause of morbidity & mortality among neonates in India, with an estimated incidence of approximately 4% in intramural live births. This present study was undertaken to study the bacteriological profile of neonatal septicemia cases and their antibiotic sensitivity pattern for planning strategy for the management of these cases. Neonatal septicemia is a life threatening emergency, and rapid treatment with antibiotics is essential for a favorable outcome. Classical empirical treatment of neonatal sepsis consists of amoxicillin & an aminoglycoside. In present study, S.aureus & Gram-negative isolates were frequently found to be resistant to amoxicillin & an aminoglycoside also, thus indicating that the use of these drugs might be ineffective. Therefore great caution is required in selection of antibiotic therapy.
Keywords: Neonatal septicemia, Bacterial Isolates & antibiotic susceptibility.
1. Neonatal morbidity & mortality; report of National Neonatal Perinatal Database. Indian Pediatr. 1997;34:1039-42.
2. Huda H.A., Goma Edet E. and Udoc Usha Rajaram, Neonatal Septicemia in Al-Jahra Hospital, Kuwait: Etiologic Agents and Antibiotic Sensitivity Patterns Med Principles Pract, 10, 145–150.
3. Singh M. (1991): Perinatal & neonatal mortality in a hospital. Indian J. Med Res., 94,1-5.
4. Kaushik, S. L., Parmar, V.R., Grover, N., Grover, P.S. and Kaushik, R. (1998): Neonatal sepsis in hospital born babies. J. Commun. Dis., 30, 147-152.
5. S. peter borriello, Patrick R. Murray, Guido Funke (ed.) (2005): Topley & Wilson’s Microbiology & Microbial Infections. Bacteriology(V1) p. 509-524.
6. Baron EJ, Finegold SM (ed.) Overview of conventional methods for bacterial identification. Chapter 13, In: Baily and Scott’s Diagnostic Microbiology ( Mosby Publishers, St. Louis ) 1994:167.
7. M100-S18 performance standard for antimicrobial susceptibility testing – 2008 CLSI.
8. Sindhu S,Amuchou S S, and Kamala S. 2011. Choice and duration of antimicrobial therapy for Neonatal sepsis and meningitis. International Journal of Pediatrics. 1-9.
9. Kumhar GD, VG Ramchandran, Piyush Gupta at al. Bacteriological analysis of blood clture isolates from neonates in a tertiary care hospital in india. J Health Popul Nutr 2002 Dec;20(4):343-347.
10. I Roy, A Jain, M Kumar, SK Agarwal at al. Bacteriology of neonatal septicemia in a tertiary care hospital of northern India. Indian J Med Microbiology 2002;20(3):156-159.
11. Madhu Sharma, Nidhi Goel, Uma Choudhary, Ritu Aggarwal, DR Arora et al. Bacteraemia in children. Indian J Pediatr 2002;69(12):1029-1032.