Abstract

Objective: To study the treatment of Cissu squadrangularis Linn and Zingiber officinalis Rosc on osteoarthritis patients in south India

Methods: 60 osteoarthritis patients were selected and divided into group A, B and C (each group consist of 20 patients); data were collected before and after treatment of following groups: Group A–Cissus quadrangularis linn-5gm,Group B-Zingiber officinale rosc-5gm. Group C - Treatment of Cissus quadrangularis linn +Zingiber officinale rosc-5 gm/dose, all groups twice a day, orally with luke warm water.

Results: cracking pain in joints was reduced after treatment of group ‘B’, ‘C’ 70% and group ‘A’ only 25% cases were relief from the symptom. Group ‘B’, ‘C’ (p<0.001), A (p<0.0001) were statistically significant.90 % of cases were relieved stiffness of joint at the end of treatment in group ‘B’ while ‘A‘35% ,‘C’ 45%, ‘A’,‘C’ shows statistically very significant (p<0.001) and group ‘B’ was  extremely significant (p<0.0001). Group A, B and C showed 15%, 70% and 75% relief from the complaint of joint pain while moving at the end of treatment. Statistically extremely significant in joint pain while moving(p<0.0001).

Conclusion: Present study significant reduction of cracking pain in joints after treatment of Zingiber officinalerocs or Cissus quadrangularislinn + Zingiber officinale rocs, Stiffness of joint relieved after treatment of Zingiberofficinale rocs. Reduced Joint pain while moving after treatment with combination therapy of Cissus quadrangularis Linn.+ Zingiber officinalis Rosc.

Key Words: Osteoarthritis, Ayurvedic treatment.

1.      Buckwalter JA, Lane NE. Athletics and osteoarthritis. Am J Sports Med 1997; 25:873-81.

2.      Gupta KB, Duryea J, Weissman BN. Radiographic evaluation of osteoarthritis. RadiolClin. North Am. 2004; 42:11-41.

3.      Dieppe PA. Clinical features and diagnostic problems in osteoarthritis. In: Klipple JH, Dippe PA. Eds. Practical Rheumatology. London: Mosby; 1995:141-56.

4.      Felson DT. Epidemiology of osteoarthritis. In: Brandt KD, Doherty. M, Lohmander S. eds. Osteoarthritis. 2nd ed. Oxford: Oxford University Press; 2003:9-16

5.      Jordan KM, Arden NK, Doherty M, et al.,. EULAR recommendations 2003—an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT). Ann Rheum Dis 2003; 62:1145-55

6.      Oliveria SA, Felson DT, Reed JI, Cirillo PA, Walker AM. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum 1995; 38:1134-41.

7.      American College of Rheumatology. Recommendations for the medical management of osteoarthritis of the hip and knee 2000 update. Arthritis Rheum 2000; 43:1905-15

8.      Wood DD, Ihrie EJ, Hamerman D. Release of interleukin-1 from human synovial tissue in vitro. Arthritis Rheum 1985; 28: 853–62.

9.      Pelletier JP, DiBattista JA, Roughley P, McCollum R, Martel- Pelletier J. Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am 1993; 19: 545–68.

10.  Pelletier JP, Roughley PJ, DiBattista JA, McCollum R, Martel- Pelletier J. Are cytokines involved in osteoarthritic pathophysiology? Semin Arthritis Rheum 1991; 20: 12–25

11.  LeGrand A, Fermor B, Fink C, Pisetsky DS, Weinberg JB, Vail TP, Guilak F. Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis Rheum 2001; 44: 2078–83

12.  Kobayashi M, Squires GR, Mousa A, et al,. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum 2005; 52:128–35

13.  Pavelka K, Trc T, Karpas K, et al,. The Efficacy and Safety of Diacerein in the Treatment of Painful Osteoarthritis of the Knee: A randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period. Arthritis Rheum 2007; 56: 4055–64.

14.  Patwardhan B, Vaidya A, Chorghade M. Ayurveda and natural products drug discovery. CurrSci 2004;86:789–99.

15.  Thatte U, Chhabria S, Karandikar SM, Dahanukar S. Immunotherapeutic modifications by Indian medicinal plants. Indian Drugs 1987; 25:85-7

16.  Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999;13:275-91