References
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., Mustelin, T., 2004. Protein Tyrosine Phosphatases in the Human Genome. Cell 117, 699–711. doi:10.1016/j.cell.2004.05.018
2. Attisano, L., Wrana, J.L., 2002. Signal transduction by the TGF-beta superfamily. Science 296, 1646–7. doi:10.1126/science.1071809
3. Ball, S.G., Shuttleworth, C.A., Kielty, C.M., 2007. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol. 177.
4. Chen, S.J., Yuan, W., Lo, S., Trojanowska, M., Varga, J., 2000. Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta. J. Cell. Physiol. 183, 381–92. doi:10.1002/(SICI)1097-4652(200006)183:3<381::AID-JCP11>3.0.CO;2-O
5. Chua, F., Gauldie, J., Laurent, G.J., 2005. Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Biol. 33, 9–13. doi:10.1165/rcmb.2005-0062TR
6. Cosgrove, G.P., Brown, K.K., Schiemann, W.P., Serls, A.E., Parr, J.E., Geraci, M.W., Schwarz, M.I., Cool, C.D., Worthen, G.S., 2004. Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. Am. J. Respir. Crit. Care Med. 170, 242–51. doi:10.1164/rccm.200308-1151OC
7. Datta, P.K., Blake, M.C., Moses, H.L., 2000. Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 275, 40014–9. doi:10.1074/jbc.C000508200
8. Derynck, R., Zhang, Y.E., 2003. Smad-dependent and Smad-independent path-ways in TGF-β family signalling. Nature 425, 577–584. doi:10.1038/nature02006
9. Ebina, M., Shimizukawa, M., Shibata, N., Kimura, Y., Suzuki, T., Endo, M., Sasano, H., Kondo, T., Nukiwa, T., 2004. Heterogeneous Increase in CD34-positive Alveolar Capillaries in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 169, 1203–1208. doi:10.1164/rccm.200308-1111OC
10. Gharaee-Kermani, M., Ullenbruch, M., Phan, S.H., 2005. Animal models of pulmonary fibrosis. Methods Mol. Med. 117, 251–9. doi:10.1385/1-59259-940-0:251
11. Gong, F., Gu, W., Tang, H., Lin, Y., Wang, W., Kang, M., 2005. [Pathophys-iology of bleomycin-induced pulmonary hypertension in immature rabbits]. Zhejiang Da Xue Xue Bao. Yi Xue Ban 34, 237–42.
12. Gu, L., Zhu, Y.-J., Yang, X., Guo, Z.-J., Xu, W.-B., Tian, X.-L., 2007. Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol. Sin. 28, 382–91. doi:10.1111/j.1745-7254.2007.00468.x
13. Gueders, M.M., Foidart, J.M., Noel, A., Cataldo, D.D., 2006. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases. Eur. J. Pharmacol. 533, 133–144. doi:10.1016/j.ejphar.2005.12.082
14. Hanks, S.K., Quinn, A.M., Hunter, T., 1988. The protein kinase family: conse-rved features and deduced phylogeny of the catalytic domains. Science 241, 42–52.
15. Huang, F., Chen, Y.-G., 2012. Regulation of TGF-β receptor activity. Cell Biosci. 2, 9. doi:10.1186/2045-3701-2-9
16. Jakobsson, L., Kreuger, J., Holmborn, K., Lundin, L., Eriksson, I., Kjellén, L., Claesson-Welsh, L., 2006. Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis. Dev. Cell 10, 625–34. doi:10.1016/j.devcel.2006.03.009
17. Koch, S., Tugues, S., Li, X., Gualandi, L., Claesson-Welsh, L., 2011. Signal transduction by vascular endothelial growth factor receptors. Biochem. J. 437, 169–83. doi:10.1042/BJ20110301
18. Lu, Y., Azad, N., Wang, L., Iyer, A.K. V, Castranova, V., Jiang, B.-H., Rojanasakul, Y., 2010. Phosphatidylinositol-3-kinase/-akt regulates bleomycin-induced fibroblast proliferation and collagen production. Am. J. Respir. Cell Mol. Biol. 42, 432–41. doi:10.1165/rcmb.2009-0002OC
19. Maharaj, A.S.R., Saint-Geniez, M., Maldonado, A.E., D’Amore, P.A., 2006. Vascular endothelial growth factor localization in the adult. Am. J. Pathol. 168, 639–48. doi:10.2353/ajpath.2006.050834
20. Massagué, J., Chen, Y.G., 2000. Controlling TGF-beta signaling. Genes Dev. 14, 627–44.
21. McMahon, S., Charbonneau, M., Grandmont, S., Richard, D.E., Dubois, C.M., 2006. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J. Biol. Chem. 281, 24171–81. doi:10.1074/jbc.M604507200
22. Meadows, K.N., Bryant, P., Pumiglia, K., 2001. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J. Biol. Chem. 276, 49289–98. doi:10.1074/jbc.M108069200
23. Moustakas, A., Heldin, C.-H., 2005. Non-Smad TGF-β signals. J. Cell Sci. 118. 3573-84. doi: 10.1242/jcs.02554
24. Murakami, M., Zheng, Y., Hirashima, M., Suda, T., Morita, Y., Ooehara, J., Ema, H., Fong, G.-H., Shibuya, M., 2008. VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler. Thromb. Vasc. Biol. 28, 658–64. doi:10.1161/ATVBAHA.107.150433
25. Nobel, J.J., Norman, G.K., 2003. Emerging Information Management Technologies and the Future of Disease Management. Dis. Manag. 6, 219–231. doi:10.1089/109350703322682531
26. Peão, M.N., Aguas, A.P., de Sá, C.M., Grande, N.R., 1994. Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin. Anat. Rec. 238, 57–67. doi:10.1002/ar.1092380108
27. Piek, E., Heldin, C.H., Ten Dijke, P., 1999. Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J. 13, 2105–24.
28. Radha, V., Nambirajan, S., Swarup, G., 1996. Association of Lyn tyrosine kinase with the nuclear matrix and cell-cycle-dependent changes in matrix-associated tyrosine kinase activity. Eur. J. Biochem. 236, 352–9.
29. Renzoni, E.A., Walsh, D.A., Salmon, M., Wells, A.U., Sestini, P., Nicholson, A.G., Veeraraghavan, S., Bishop, A.E., Romanska, H.M., Pantelidis, P., Black, C.M., du Bois, R.M., 2003. Interstitial vascularity in fibrosing alveolitis. Am. J. Respir. Crit. Care Med. 167, 438–443. doi:10.1164/rccm.200202-135OC
30. Shi, Y., Massagué, J., 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113, 685–700.
31. Shu, X., Wu, W., Mosteller, R.D., Broek, D., 2002. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22, 7758–68.
32. Steurer, M., Zoller, H., Augustin, F., Fong, D., Heiss, S., Strasser-Weippl, K., Gastl, G., Tzankov, A., 2007. Increased angiogenesis in chronic idiopathic myelofibrosis: vascular endothelial growth factor as a prominent angiogenic factor. Hum. Pathol. 38, 1057–64. doi:10.1016/j.humpath.2006.12.011
33. Tuder, R.M., Yun, J.H., 2008. Vascular endothelial growth factor of the lung: friend or foe. Curr. Opin. Pharmacol. 8, 255–60. doi:10.1016/j.coph.2008.03.003
34. Turner-Warwick, M., 1963. Precapillary systemic-pulmonary anastomoses. Thorax 18, 225–37. doi:10.1136/THX.18.3.225
35. Verrecchia, F., Chu, M.-L., Mauviel, A., 2001. Identification of Novel TGF- /Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation Approach. J. Biol. Chem. 276, 17058–17062. doi:10.1074/jbc.M100754200
36. Wollin, L., Wex, E., Pautsch, A., Schnapp, G., Hostettler, K.E., Stowasser, S., Kolb, M., 2015. Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis. Eur. Respir. J. 45, 1434-45 doi: 10.1183/09031936.00174914
37. Wrighton, K.H., Lin, X., Feng, X.-H., 2009. Phospho-control of TGF-β superfamily signaling. Cell Res. 19, 8–20. doi:10.1038/cr.2008.327