Comparative Study of Oral Clonidine and Diazepam As Premedicants in Children

Title: Comparative Study of Oral Clonidine and Diazepam As Premedicants in Children

Authors: Anoop Prabhakaran, Raju Rajan, Geetha N K

DOI: https://dx.doi.org/10.18535/jmscr/v5i6.125

Abstract

In a prospective observational study, the efficacy of oral Clonidinevis a vis Diazepamas premedicant was assessed in children undergoing elective surgery. Eighty children aged 2-12 years, undergoing general anaesthesia were studied. Forty children received oral diazepam 0.2 mg/kg (group A) and another forty children received oral clonidine 2 μg/kg(group B) 90minutes before induction of anaesthesia. The level of sedation, parental separation score, quality of mask acceptance and occurrence of complications were noted and compared between the groups. Clonidine 2 μ/kg produced sedation better than diazepam 0.2 mg/kg (p > 0.001). Parental separation score and quality of mask acceptance was much better in the clonidine group (P> 0.001).Though hypotension and bradycardia were observed in 5% of the clonidine group, it was not clinically significant. Based on composite score, none of the children in diazepam group had an acceptable score as compared to 32.5% children in the clonidine group. 60% of the diazepam group children had an unacceptable score

Keywords: Diazepam, Clonidine, Premedication.

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