Aim: To study the effect of various variables eg. S. Cholesterol, stress, physical activity and Socioeconomic status on platelet stickiness in subjects of Gwalior region in Central India. These tests were done to investigate the physiological norms to evaluate the possible role of various factors affecting the parameter of platelet stickiness as high residual reactivity of platelet moves forward thromboembolic complications.

Material Methods: The present study made in 200 apparantly healthy subjects including 160 males and 40 females, belonging to 16-40 years, were selected randomly. After noting careful history, thorough clinical examnation was done and recording of pulse and blood pressure were taken .Stess was assessed by Taylor’s Personality scale of manifest anxiety. Serum Cholesterol was estimated by Sackett’s method for total cholesterol. Platelet Stickiness was estimated by Mac Donald’s Modification of Payling Wright’s Technique. Platelet count was done by Rees & Ecker technique.

Observation & Result: The value of platelet stickiness was observed to be 10-50% with an average of 21.6%±8.6%. Values were significantly lower in females. No significant correlation was found between age, weight and platelet stickiness. Physical activity significantly lowered platelet stickiness as compared to values in sedentary group. It was also higher in non-vegetarian than in vegetarian group. Also in those consuming saturated fat in diet, it was found to be higher. Smoking also has been shown to increase platelet stickiness, thus making smoking one of the causative and risk factors for thromboembolic diseases.

In addition, mental stress of examination raised the values of platelet stickiness significantly, thus, proving stress to be one of the contributing factor in worsening the prognosis of the illness and in appearance of clinical symptoms often following emotional stress. However, platelet stickiness values rise with rise in blood pressure figures.

Keywords:  platelet stickiness  thromboembolic phenomenon Rees & eckertechnique.