Title: Association of Ischemia Modified Albumin with Pregnancy Induced Hypertension
Authors: Dr A.Mangala Geetha, MD DGO DNB, Viswanath Selvam, Vinodhini Shanmugam
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.109
Abstract
INTRODUCTION
Pre-eclampsia occurs in 5% to 8% of pregnancies worldwide and is the second leading cause of direct maternal and fetal deaths [1]. Its prevalence in India is 54% and 56.2% in urban and rural communities respectively. Its occurrence in Tamil Nadu is 47.4 % to 48.7%[2].
Pre-eclampsia affects both mother and fetus. It may lead to eclampsia, HELLP syndrome, ischemic stroke, liver dysfunction and acute respiratory distress syndrome (ARDS)[3].
Abnormal placental vascular development is the basis of common obstetric disorders such as preeclampsia and intrauterine growth restriction[4]. Preeclampsia associated with defective endovascular trophoblastic invasion and inadequate remodeling of uterine spiral arteries leads to hypoxic intrauterine environment and generation of reactive oxygen species (ROS) which is implicated in its pathogenesis[5].
References
1. Roberts JM, Lain KY : Recent insights into the pathogenesis of pre-eclampsia. Placenta 2002, 23: 359–72.
2. Sutapa Agrawal1* , Gagandeep K Walia1Prevalence and risk factors for Pre-eclampsia in Indian women: a national cross sectional study 1 South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India.
3. Arulkumaran, N.; Lightstone, L. (Decem-ber 2013). "Severe pre-eclampsia and hypertensive crises". Best Practice & Research Clinical Obstetrics & Gynaecology 27 (6): 877–884. doi:10.1016/j.bpobgyn.2013.07.003.
4. Martin AM, Bindra R, Curcio P, et al. Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11-14 weeks of gestation. Ultrasound obstet Gynecol 2001;18:583-6.
5. Papageorghiou AT, Prefumo F, Leslie K, Gaze DC. Collinson PO Thilaganathan B. Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia- modified albumin. Hum Reprod 2008; 23: 803-806.
6. Federico Prefumo1, David C Gaze2, Aris T Papageorghiou1, Paul O Collinson2 and Baskaran Thilaganathan1,3 First trimester maternal serum ischaemia-modified albumin: a marker of hypoxia-ischaemia-driven early trophoblast development 1Fetal Medicine Unit, Division of Obstetrics and Gynaecology, St. George’s University of London, London SW17 0RE, UK; 2Department of Clinical Biochemistry, St George’s Hospital NHS Trust, London SW17 0QT, UK
7. Cerdeira AS, Karumanchi SA. Biomarkers in preeclampsia. In: Edelstin CL, editor. Biomarkers of kidney disease. 1st ed. Amsterdam; Boston: Academic Press/Elsevier; 2011.p.385-426.
8. Reem Mustafa,1,2 Sana Ahmed,1,2 Anu Gupta,1 and Rocco C. Venuto1,2. A Comprehensive Review of Hypertension in Pregnancy Division of Nephrology, Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14215, USA 2Renal Department, Erie County Medical Center, Buffalo, NY 14215,USA Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005;365:785-99.
9. Khan KS, Wojdyla D, Say L, et al. WHO analysis of causes of maternal death: a systematic review. Lancet 2006;367:1066-74. Walker JJ. Pre-eclampsia. Lancet 2000;356:1260-5.
10. Doğan K1, Guraslan H1, Çankaya A1, Dağdeviren H1, Ekin M1 Ischemia-Modified Albumin (IMA): A Novel Marker for Preeclampsia Independent of Uterine Artery Notching Identified by Doppler Ultrasound. 2015 Nov;34(4):516-524. Epub 2015 Dec 4.
11. Wallis AB, Saftlas AF, Hsia J, Atrash HK. Secular Trends in the Rates of Preeclampsia, Eclampsia, and Gestational Hypertension, United States, 1987-2004. Am J Hypertens. 2008; 21(5):521–526. [PubMed: 18437143]
12. Duley L. The Global Impact of Pre-eclampsia and Eclampsia. Semin Perinatol. 2009; 33(3):130137. [PubMed: 19464502]
13. Cousens S, Blencowe H, Stanton C, Chou D, Ahmed S, Steinhardt L, Creanga AA, Tunçalp O, Balsara ZP, Gupta S, Say L, Lawn JE. National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Lancet, 2011, Apr 16;377(9774):1319-30.
14. American College of Obstetricians and Gynecologists, Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013 Nov. 122 (5):1122-31. [Medline]
15. Epidemiology of preeclampsia: Impact of obesity Arun Jeyabalan, MD Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
16. Preeclampsia.Author: Kee-Hak Lim, MD; Chief Editor: Ronald M Ramus, MD more... Updated: Sep 15, 2016
17. Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate a strategy for successful endovascular invasion? J Clin Invest 1997; 99 : 2139-51. Back to cited text no. 9 [PUBMED]
18. Maynard SE, Karumanchi SA. Angiogenic factors and preeclampsia. Semin Nephrol 2011; 31 : 33-46. Back to cited text no. 7 [PUBMED]
19. Lagana AS, Favilli A, Triolo O, Granese R,Gerli S. Early serum markers of pre-eclampsia: are we steepping forward?. J Matern Fetal Neonatal Med.2015 Nov 23. 1-5.[Medine].
20. RobertsJM,HubelCA.Isoxidativestressthelinkinthetwo-stagemodelof pre-eclampsia? [comment].Lancet.1999;354:788–789.
21. Marx G, Chevion M. Site-specific modification of albumin by free radicals. Biochem J. 1985;236:397–400. [PubMed]
22. Roy D, Quiles J, Gaze DC, Collinson P, Kaski JC et al. (2006) Role of reactive oxygen species on the formation of the novel diagnostic market ischaemia modified albumin. Hearth 92: 113-114.10.1136/hrt.2004.049643 [PubMed]
23. Role of maternal serum ischemia modified albumin as a biochemical marker in preeclampsia. Jyotirmayee Bahinipati1, Prakash Chandra Mohapatra2, Tapaswini Pradhan3 Department of Biochemistry Kalinga Institute of Medical Sciences Bhubaneshwar Odisha India. Department of Biochemistry SCB Medical College and HospitalCuttack Odisha India. Department of Biochemistry Kalinga Institute of Medical Sciences Bhubaneshwar Odisha India.
24. Bahinipati J, Mohapatra PC, Pradhan T. Role of maternal serum ischemia modified albumin as a biochemical marker in preeclampsia. Biomed Res. 2014;25(2):153–6.
25. Steel SA, Pearce JM, Chamberlain G. Doppler ultrasound of the uteroplacental circulation as a screening test for severe pre-eclampsia with intra-uterine growth retardation. Eur J Obstet Gynecol Reprod Biol1988;28:279-87. [PubMed]
26. Bolte AC, Dekker GA. Uterine artery Doppler as screening tool for preeclampsia. In Wildschut HJ, Weiner CP, editors. When to screen in obstetrics and gynecology. Philadelphia: Saunders Elsevier; 2006. p. 408-19.
27. Coomarasamy A, Papaioannou S, Gee H, et al. Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler: a meta-analysis. Obstet Gynecol 2001;98:861-6. [PubMed]
28. Arch Gynecol Obstet. 2005 Jan;271(1):46-52. Epub 2004 Jun 8.
29. Doppler ultrasound of the uterine artery in the prediction of severe complications during low-risk pregnancies.
30. Schwarze A1, Nelles I, Krapp M, Friedrich M, Schmidt W, Diedrich K, Axt-Fliedner R. The Role of Uterine Artery Doppler Sonography in Predicting Pre Eclampsia at 14-20 Weeks of Gestation Dr. (Brig) K. Sahoo, Dr. Pramod Shaha, Dr. Shweta Bhairagond,Dr. Vinay Raj R. Krishna Institute of Medical Sciences University
31. Albaiges G, Missfelder-Lobos H, Lees C, et al. One-stage screening for pregnancy complications by color Doppler assessment of the uterine arteries at 23 weeks’ gestation. Obstet Gynecol 2000;96:559-64. 31.Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot studySapna Vyakaranam1,*, Aparna Varma Bhongir1, Dakshayani Patlolla1, and Rekha Chintapally2 1Department of Biochemistry, Mediciti Institute of Medical Sciences, Ghanpur-501401, Medchal Mandal Ranga Reddy, Telangana, India 2Department of Gynaecology & Obstetrics, Mediciti Institute of Medical Sciences, Ghanpur-501401, Medchal Mandal Ranga Reddy, Telangana, India First trimester maternal serum ischaemia-modifiedalbumin: a marker of hypoxia-ischaemia-driven earlytrophoblast development.
32. Federico Prefumo1, David C Gaze2, Aris T Papageorghiou1, Paul O Collinson2 and Baskaran Thilaganathan1,3 1Fetal Medicine Unit, Division of Obstetrics and Gynaecology, St. George’s University of London, London SW17 0RE, UK; 2Department of Clinical Biochemistry, St George’s Hospital NHS Trust, London SW17 0QT, UK
33. Assessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimester. Suna Özdemir a,,Aysel Kıyıcı bOsman Balci aHalime Göktepe aHümeyra Çiçekler bÇetin Çelika aSelçuk University, Meram Medical Faculty, Department of Obstetrics and Gynecology, Konya, Turkey bSelçuk University, Meram Medical Faculty, Department of Biochemistry, Konya, Turkey
34. Papageorghiou AT, Prefumo F, Leslie K, et al. Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia-modified albumin. Hum Reprod 2008;23:803–6
35. Rossi A, Bortolotti N, Vescovo S, et al. 2013 Ischemia-modified albumin in pregnancy. Eur J Obstet Gynecol Reprod Biol 2013;170:348–51.
36. Ischemia-Modified Albumin (IMA): A Novel Markerfor Preeclampsia Independent of Uterine ArteryNotching Identified by Doppler Ultrasound
37. Keziban Doğan, Hakan Guraslan, Atilla Çankaya, Hediye Dağdeviren & Murat Ekin
