Abstract
Introduction: Optic neuritis (ON) is an acute inflammatory disorder of the optic nerve. The disease is characterized by unilateral or bilateral acute diminuition of vision, often accompanied by periocular pain maximally associated with eye movements. The majority of cases are idiopathic in origin. This study was undertaken to evaluate the clinical, neuroradiological, electrophysiological profile on patients of optic neuritis in context of various studies.
Materials: The study is an observational study. The study was carried out in OPD patients and admitted patients in department of medicine and department of Ophthalmology ,Gandhi Medical College, Bhopal and and associated Hamidia Hospital Bhopal (M.P.).Patients presenting with unilateral or bilateral diminuition of vision less than 4 weeks, presence of relative afferent pupillary defect, dyschromatopsia and normal or swollen optic disc on fundus examination were included in this study.Optic neuropathies like ischemic, toxic, hereditary, compressive and patients under age of 15 years were excluded from study. All patients were subjected to history, clinical examination, visual evoked potential (VEP), MRI brain with orbit.
Observations: 75 eyes of 61 patients were examined. Mean age was 35.29 years .Female preponderance was seen(65.5%). All patients presented with diminuition of vision less than 4 weeks, and defective colour vision. Bilateral involvement seen in 14 patients (23%). Papillitis (58% of eyes) was most common fundus finding. Prolonged P100 latency was seen in 44 patients (72%) on VEP.MRI Brain showed intracranial demyelination in 23patients(38%).MRI Orbit showed abnormal findings in 77% patients
Conclusions: Majority of patients of Optic neuritis of Central India presented with poor visual acquity. Papillitis is frequently seen in patients. Prolonged P100 latency is most common finding seen on VEP. Therefore, VEP, MRI Brain with Orbit is highly recommended in patients of ON for proper management. Clinical profile of ON in Central India patients is different from that seen in Western population.
Keywords: Optic neuritis,multiple sclerosis, relative afferent papillary defect, visual evoked potential.
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DOI: https://dx.doi.org/10.18535/jmscr/v5i6.105
