Title: Clinicomorphological and Immunohistochemical Profile of Lung Carcinoma Specimens Received at a Tertiary Care Centre
Authors: Himanshi Diwan, Ajay Yadav, Jayanti Mehta
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.50
Abstract
Introduction: Lung cancer is the major cause of mortality worldwide and its incidence is rising in India. Sub classifying non small cell carcinoma is vital for prognosis and treatment of the patients. Several immunohistochemical markers have been studied to serve this purpose. In small samples, TTF-1 and p63 are sufficient to further classify the non small cell lung carcinoma. The present study aimed to study morphology and imunohistochemical profile of various lung carcinoma.
Methods: A total of 65 cases of lung carcinoma were studied in a span of 18 months. All benign conditions were excluded from the study. Hematoxylin and eosin stained sections were studied and immunohistochemical panel was applied on the selected cases.
Results: 54 cases were of non small cell lung carcinoma, 10 were of neuroendocrine tumours and 1 was a rare case of pulmonary blastoma. Maximum cases were found to be in the age group of 51-60 years. Squamous cell carcinoma constituted 47.69% of cases followed by adenocarcinoma accounting for 32.30% of cases. TTF-1 was 88.89% sensitive in detecting adenocarcinoma and p63 was positive in 80% of squamous cell carcinoma. Chromogranin was 88.88% sensitive for neuroendocrine tumours.
Discussion: TTF-1, p63, CK7, CK5/6 help in differentiating poorly differentiated tumours and hence serve as a prognostic marker in lung carcinomas.
Keywords: Lung carcinoma, immunohistochemistry, targeted therapy.
