Title: Comparative Study of Buccal Midazolam and I.V Diazepam for Acute Treatment of Seizure in Pediatrics Age Group
Authors: Rakesh Ranjan Kumar, Rizwan Ahmar
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.205
Abstract
Background: Seizure episode is a common pediatrics neurological emergency requiring hospitalization. Urgent treatment of seizure results in favorable prognosis. Buccal Midazolam can be better drugs than intravenous (I/V) diazepam as first choice in situation where there is difficulty in accessing the i. v line urgently or in remote area where availability of trained person to control seizure is limited.
Materials and Methods: Total 50 (29 boys, 21 girls) patients were enrolled in the study. In the study group A, patients received buccal Midazolam (0.3 mg/kg/ dose) and in control group B, patient received I.V Diazepam (0.2 mg/kg/dose).
Results: In 24 cases (96%) of both group A and B, seizures were aborted by giving buccal Midazolam and i.v Diazepam respectively (P > 0.05). The mean time needed for cessation of seizures in group A was 90 ± 150 seconds (1.68 min) with the lowest time being 32 seconds and highest being 289 seconds while it was 80 ± 130 seconds (1.4 minutes) in group B with the lowest being 31 seconds and the highest being 299 seconds. The difference in time taken to control seizures between two groups was statistically insignificant (P = 0.641). No significant side effects were seen in either group.
Conclusions: Buccal Midazolam is quite safe drugs, equally effective than I.V Diazepam in controlling the prolonged seizure in children and can be given easily.
Keywords: prolonged seizure, Buccal Midazolam, i.v Diazepam, Efficacy.
