Abstract
Background: NAFLD is considered the most common cause of chronic liver disease worldwide. In the general US population, the prevalence of NAFLD is estimated to be approximately 30%, but much higher estimates are reported in selected high-risk populations, such as Hispanics, obese persons, and patients with type 2 diabetes mellitus (T2DM) or with metabolic syndrome. The purpose of this study to correlate the biochemical & radiological changes in non alcoholic fatty liver disease patients compare with obese patients.
Material & Methods: 41 cases out of which 25 were male and 16 females recruit for this study. In this study biochemical and radiological parameters were determined.
Statistical Analysis: Comparison of radiological grade of fatty liver and biochemical parameters we used Pearson Chi square test.
Results: All the biochemical parameters were increased. When the radiological grade was compared with the biochemical findings (FBS, TG and SGPT) individually through Pearson’s formula the p value (>0.05) thus found were not statistically significant for any of the biochemical tests.
Conclusion: In this study we concluded that Non-alcoholic fatty liver disease (NAFLD), radiological and biochemical findings give a good correlation and are equally helpful in assessing the severity of NAFLDS.
Keyword: NAFLD, obesity, body mass index, CHD, Diabetes Mellitus.
References
1. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology. 2005; 42:44–52. [PubMed]
2. Adams LA, Lymp JF, Sauver J, St, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005; 129:113–121. [PubMed]
3. Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–1850. [PubMed]
4. Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Dalla Man C, et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A. 2006; 103:18273–18277. [PubMed: 17114290]
5. Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology. 2003; 124:71–79. [PubMed: 12512031]
6. Marcos A, Fisher RA, Ham JM, Olzinski AT, Shiffman ML, Sanyal AJ, et al. Selection and outcome of living donors for adult to adult right lobe transplantation. Transplantation. 2000; 69:2410–2415. [PubMed: 10868650]
7. Hilden M, Christoffersen P, Juhl E, Dalgaard JB. Liver histology in a ‘normal’ population--examinations of 503 consecutive fatal traffic casualties. Scand J Gastroenterol. 1977; 12:593–597.[PubMed: 918553]
8. Lee RG. Nonalcoholic steatohepatitis: a study of 49 patients. Hum Pathol. 1989; 20:594–598. [PubMed: 2656500]
9. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008; 40:1461–1465. [PubMed: 18820647]
10. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004; 40:1387–1395. [PubMed: 15565570]
11. Angulo P: Nonalcoholic fatty liver disease. N Engl J Med 346(16):1221–1231, 2002
12. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ. Clinical features and natural history ofnon-alcoholic steatosis syndromes.Semin Liver Dis 2001; 21:17-26.
13. Singh DK, Rastogi A, Sakhuja P, Gondal R, Sarin SK.Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients.Indian J Pathol Microbiol[ serial online]2010;53:408-13.
14. Dixon JB, Bhathal PS, Hughes NR, et al. Non-alcoholic fatty liverdisease: improve-ement in liver histological analysis with weight loss. Hepatology 2004;39:1647-54.
15. Lazo M, Clark JM. The epidemiology of non-alcoholic fatty liver disease: a global perspective. Semin Liver Dis 2008;339-50.
16. Bellentini S, Bedogni G,Miglioli L, et al. The epidemiology of fatty liver. Eur J Gastroenterol Hepatol 2004;16:1087-93.
17. Huang HL, Lin WY, Lee LT, Wang HH, Lee WJ, Huang KC. Metabolic syndrome is related to non-alcoholic steatohepatitis in severely obesesubjects. 2007 Nov; 17(11):1457-63.
18. Sujimoto M, Sadamoto T, Nonako H. Clinical and pathological differences between alcoholic hepatitis and non-alcoholic steatohepatitis.Nihon Arukoru yakubustu Igakkai Zasshi 2003;38:34-45.
19. Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine aminotransterase: potential value in differentiating non-alcoholic steatosis from alcoholic liver disease. AM J Gastroenterol 1999;94: 1018-22.
20. Dixon JB, Bhanthal PS, O”Brien PE.Non-alcoholic fatty liver disease: predictors of non-alcoholic steatohepatitis and liver fibrosis in the severly obese. Gastroenterology 2001; 121(1): 91-100.
21. Caballería L, Pera G, Auladell MA, Torán P, Muñoz L, Miranda D, Alumà A, Casas JD, Sánchez C, Gil D, Aubà J, Tibau A, Canut S, Bernad J, Aizpurua MM. Prevalence and factors associated with the presence of non-alcoholic fatty liver disease in an adult population in Spain. 2010 Jan; 22(1):24-32.
22. Clark JM, Brancati FL, Diehl AM. Non-alcoholic fatty liver disease, Gastroente-rology 2002; 122(6) : 1649-57.