Abstract
Multidrug resistance in Salmonella Typhi has emerged as a significant problem. Given the difference in the sensitivity patterns reported for Salmonella Typhi, this study aimed to evaluate antimicrobial susceptibility patterns of Salmonella Typhi in RMMCH, Chidambaram, India. Salmonella Typhi positive blood cultures from children up to 12 years of age, over a period of 22 months from November 2014 to August 2016 were analyzed. Kirby-Bauer disc diffusion method was used to evaluate antimicrobial susceptibility.
Results: Of the total of 20 isolates studied, all the isolates were susceptible to ceftriaxone, Cefixime and Azithromycin. most were responsive to Ciprofloxacin, Nalidixic acid and Chloramphenicol. Maximum resistant noted against Ampicillin. In this study 10% of isolates were MDR.
Key words: Antibiotic sensitivity, Salmonella typhi, multidrug resistant typhoid fever, Pediatric age group.
References
1. Background document: The diagnosis, treatment and prevention of typhoid fever. world health organization.2003; WHO/V& B/ 03.07: 1-38
2. Zulfiqar Ahmed Bhutta. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier 2016; 1388-1392.
3. Parthasarathy A, RitabrataKundu, Rohit Agarwal. Textbook of pediatric infectious diseases. Indian academy of pediatrics infectious disease chapter. New delhi. Jaypee brothers medical publishers pvt ltd. 2013;418-423
4. Chandrashekar, Anil Kumar YC, KirandeepSodhi and Dalal S.S. A Study of clinical and laboratory profile of enteric fever in pediatric age group. International Journal of Basic and Applied Medical Sciences 2013; 3(3): 16-23
5. Joshi BG, Keyal K, Pandey R, Shrestha BM. Clinical Profile and Sensitivity Pattern of Salmonella Serotypes in Children: A Hospital Based Study. Journal of Nepal Paediatric Society. 2011;31(3): 180-83.
6. Akhtar, Indu Shukla, Fatima Khan and Anjumparwez., A Multi-drug Resistant Salmonella enterica Subspecies enterica Serotype Typhi: A Diagnostic and Therap-eutic Challenge. International Journal of Current Microbiology and Applied Sciences. 2015; Special Issue-1: 19-25
7. Riyazchungathu, Jayavardhana A. Current pattern of Salmonella Typhi antimicrobial susceptibility in the era of antibiotic abuse. Indian Journal of Basic and Applied Medical Research. 2015;5(1) :400-404.
8. Udayakumar, P M Swathi, K Pushpalatha, G S Ravi Current antibiogram pattern of Salmonella typhi and paratyphi isolates and response to treatment in a tertiary care center.Indian Journal of Child Health. 2016; 3(2): 120-124.
9. Altaf Ahmed Talpur, Nand Lal Kella, Abdul Rashid Surahio, Muhammad Javed, Akmal Jamal. Sensitivity pattern of salmonella Typhi in patients with typhoid small Bowel perforations. Quarterly medical channel.2012; 19(2): 93-96.
10. Nilesh D. Patel, Rakesh M. Rajat, Rajesh S. Katara In-vitro antibiotic sensitivity pattern of salmonella typhi. International archives of integrated medicine.2015; 2(5): 1-4
11. Ranjana Hawaldar, Sadhna Sodani, Hemlata Bhilware Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh. Indian J Microbiol Res 2016;3(1):31-36.
12. Sudharshan Raj. Clinical profile and antibiotic sensitivity pattern of typhoid fever in Patients admitted to pediatric ward in a rural teaching hospital. International Journal of Medical Research & Health Sciences. 2013; 3(2): 245-249.
13. Hetal N. Jeeyani, Baldev S. Prajapati, Afroz Bloch Enteric Fever in Children - Clinical Profile, Sensitivity Patterns and Response to Antimicrobials. GCSMC Journal of Medical Sciences.2015; 4(1): 40-43.
Corresponding Author
Suresh.K.
Postgraduate, Department of Pediatrics,
Rajah Muthiah Medical College and Hospital,
Annamalai University, Annamalai Nagar – 608 002